The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Effect of adenine moiety on DNA binding property of copper(II)-terpyridine complexes, the main research direction is copper adeninylmethylphenyl terpyridine nitrate complex preparation structure DNA binding; crystal structure copper adeninylmethylphenyl terpyridine nitrate complex.SDS of cas: 89972-77-0.
Two novel copper(II) terpyridine complexes, [Cu(atpy)(NO3)(H2O)](NO3)·3H2O (1) and [Cu(ttpy)(NO3)2] (2, atpy = 4′-p-N9-adeninylmethylphenyl-2,2′:6′,2”-terpyridine; ttpy = 4′-p-tolyl-2,2′:6′,2”-terpyridine) were prepared and structurally characterized by x-ray crystallog. Both complexes show a CuN3O2 coordination in a square pyramidal (4 + 1) geometry with terpyridine acting as an equatorial ligand. For complex 1, intermol. AA base pairing interaction is observed between N6 and N1 of adjacent adenines with N6···N1 of 3.027(7) Å. A mol. dynamics simulation of the DNA binding of two complexes showed that the adenine moiety plays an important role in the intercalation of 1 into DNA. This is verified by UV, fluorescence, CD and flow linear dichroism studies. The promotional effect from the adenine moiety to the intracellular DNA binding of complex 1 is also confirmed by the inductively coupled plasma mass (ICP-MS) spectrometry data which showed a significant higher copper content in DNA isolated from complex 1 treated MCF-7 and HeLa cells.
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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI