The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one(SMILESS: O=C1O[C@H](CO)CC1,cas:32780-06-6) is researched.HPLC of Formula: 123333-71-1. The article 《Design and SAR study of a novel class of nucleotide analogues as potent anti-HCMV agents》 in relation to this compound, is published in Nucleosides & Nucleotides. Let’s take a look at the latest research on this compound (cas:32780-06-6).
We have developed a novel class of 2-phosphonate 1,3-dioxolane nucleotide analogs, from which the guanine derivative displayed weak anti-HCMV activity. Further SAR studies led to the identification of both cis and trans guanine derivatives of THF analogs as potent anti-HCMV agents, both in vitro and in vivo, compared to ganciclovir and HPMPC.
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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI