Reference of 11-Bromoundecanoic acid. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Development of technetium-99m labeled ultrafine gold nanobioconjugates for targeted imaging of folate receptor positive cancers. Author is Kumar, Dheeraj; Sakhare, Navin; Das, Soumen; Kale, Pooja; Mathur, Anupam; Mirapurkar, Shubhangi; Muralidharan, Sheela; Chaudhari, Pradip; Mohanty, Bhabani; Ballal, Anand; Patro, Pankaj.
The present work aims to develop and evaluate a radioactive technetium-99m (99mTc) labeled gold nanoparticle (NP) preparation modified with folic acid, so as to diagnose folate receptor pos. cancers viz. ovarian, breast, etc.11-Bromoundecanoic acid (UA) was synthetically modified both with folic acid and Hydrazinonicotinic acid (HYNIC) chelate at the carboxylic acid end and subsequently converted to thiol functionality at the bromo terminal to yield folic acid-UA-SH and HYNIC-UA-SH ligands resp. Gold NPs modified with folic acid and HYNIC chelator were obtained on direct addition of folic acid-UA-SH and HYNIC-UA-SH to chloroauric acid in polysorbate 80 solution under reducing conditions. Inhibition of [3H]folic acid with functionalized gold nanoparticle revealed affinity towards FR pos. KB cell lines with an IC50 9 μM. Biodistribution studies of 99mTc-labeled gold NP preparation in SCID mice bearing KB tumor showed an uptake of 1.39 ± 0.18%ID/g in tumor and 5.48 ± 0.72%ID/g in kidneys at 3 h post-injection. In vivo distribution in folic acid pre-treated animals could not establish the specificity towards folate receptors. Biol. evaluation of functionalized gold NP showed affinity towards FR pos. cancer cell lines. 99mTc-labeled NP exhibited target uptake in both in vitro and in vivo models, but folic acid inhibition could not establish the target specificity.
After consulting a lot of data, we found that this compound(2834-05-1)Reference of 11-Bromoundecanoic acid can be used in many types of reactions. And in most cases, this compound has more advantages.
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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI