The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Redox-responsive comparison of diselenide micelles with disulfide micelles》. Authors are Zhang, Longshuai; Liu, Yuancheng; Zhang, Kui; Chen, Yuanwei; Luo, Xianglin.The article about the compound:11-Bromoundecanoic acidcas:2834-05-1,SMILESS:O=C(O)CCCCCCCCCCBr).Application In Synthesis of 11-Bromoundecanoic acid. Through the article, more information about this compound (cas:2834-05-1) is conveyed.
Redox-responsive block copolymer micelles have been studied extensively as drug carriers. In this study, tri-block copolymers, methoxyl poly(ethylene glycol)-b-poly(ε-caprolactone)-SeSe-b-poly(ε-caprolactone)-b-methoxyl-poly(ethylene glycol) (mPEG-PCL-SeSe-PCL-mPEG) and methoxyl poly(ethyleneglyco)-b-poly(ε-caprolactone)-SS-b- poly(ε-caprolactone)-b-methoxyl-poly(ethylene glycol) (mPEG-PCL-SS-PCL-mPEG), were synthesized to investigate the redox sensitivity differences between diselenide and disulfide micelles. The changes of micelles in size and structure were investigated under conditions with glutathione (GSH) or H2O2. The results showed that the size and PDI of (mPEG-PCL-Se)2 micelles presented more significant variations under redox condition in comparison with (mPEG-PCL-S)2 micelles. The DOX released faster and more from diselenide micelles than disulfide micelles. The half maximal inhibitory concentration (IC50) of (mPEG-PCL-Se)2/DOX micelles was lower than that of (mPEG-PCL-S)2/DOX micelles against 4T1 and Hela cells. The amount of intracellular drug release from diselenide micelles was higher than from disulfide micelles in Hela cells with GSH 4.6 mM. Therefore, the (mPEG-PCL-Se)2 micelles similar to (mPEG-PCL-S)2 micelles are stimuli-responsive and may be more sensitive drug carriers.
After consulting a lot of data, we found that this compound(2834-05-1)Application In Synthesis of 11-Bromoundecanoic acid can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI