In 2022,Bobers, Jens; Hahn, Lisa Katharina; Averbeck, Tobias; Brunschweiger, Andreas; Kockmann, Norbert published an article in Chemie Ingenieur Technik. The title of the article was 《Reaction Optimization of a Suzuki-Miyaura Cross-Coupling using Design of Experiments》.Application In Synthesis of Tris(dibenzylideneacetone)dipalladium(0) The author mentioned the following in the article:
The combination of lab automation and design of experiments for the execution of screening experiments increases productivity and reduces error-prone manual work. A self-developed software tool allows for creating fractional-factorial exptl. design (FFED). Application of FFED on the screening of a Suzuki-Miyaura cross-coupling leads to a 93% reduced design compared to full-factorial design. The resulting regression model qual. shows the pos. effect of educt concentrations, time, and temperature and reveals the decrease in conversion at high base concentrations The experimental part of the paper was very detailed, including the reaction process of Tris(dibenzylideneacetone)dipalladium(0)(cas: 51364-51-3Application In Synthesis of Tris(dibenzylideneacetone)dipalladium(0))
Tris(dibenzylideneacetone)dipalladium(0)(cas: 51364-51-3) is used in the preparation of semiconducting polymers processed from nonchlorinated solvents into high performance thin film transistors.Application In Synthesis of Tris(dibenzylideneacetone)dipalladium(0)It is used as catalyst for the synthesis of epoxides, alpha-arylation of ketones, in combination with BINAP for the asymmetric heck arylation of olefins, site-selective benzylic sp3 palladium-catalyzed direct arylation and homoallylic diamination of terminal olefins.
Referemce:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI