62937-45-5, D-Prolinamide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
62937-45-5, Example 66; 1-f5-4- (2-Methoxv- (1 R)-methvl-ethoxv)-phenyll-4- (6-methoxy-pyridin-3-vl)-4H- f . 2, 41triazol-3-vlmethvlLpyrrolidine- (2R)-carboxylic acid amide; A mixture of the product of preparation 62 (100mg, 0. 26mol), L-prolinamide (44mg, 0. 39mmol) and potassium carbonate (72mg, 0. 51mmol) were stirred in acetonitrile (10mi), for 18 hours at room temperature, and for 6 hours at 45C. The solvent was then evaporated under reduced pressure and the residue was taken up in ethyl acetate and washed with water and brine. The organic phase was dried over sodium sulfate, concentrated in vacuo, and purified by column chromatography on silica gel, eluting with dichloromethane : methanol : 0.88 ammonia, 98: 2: 0.2, to yield the title compound, 24mg. ‘H NMR (CDC13, 400MHz) d : 1.30 (d, 3H), 1.80 (m, 2H), 2.20 (t, 1H), 2.60 (m, 1H), 3. 10 (t, 1H), 3.20 (m, 1H) 3.40 (s, 3H), 3.50 (m, 1H), 3.60 (m, 1H), 3.80 (d, 1H), 3.90 (d, 1H) 4.00 (s, 3H) 4.60 (m, 1H), 5.10 (s, 1H), 6.80 (d, 1H), 6.90 (d, 2H), 7.30 (d, 2H), 7.40 (d, 1H), 8. 10 (s, 1 H). MS APCI+ m/z 467 [MH] +
62937-45-5 D-Prolinamide 447554, acatalyst-ligand compound, is more and more widely used in various fields.
Reference£º
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/82866; (2005); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI