With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4730-54-5,1,4,7-Triazacyclononane,as a common compound, the synthetic route is as follows.
General procedure: To a solution of amine or its hydrochloride salt (1.0 mmol) in MeOH (7 mL) K2CO3(1.0 mmol for morpholine and aniline, 2.0 mmol for benzylamine and propargylamine, 3.0 mmol for valine methyl ester hydrochloride and tacd, 4.0 mmol for cyclam, 6.0 mmol for tacn tryhydrochloride) was added and the mixture was stirred for 30 min. Then alpha-halohydrazone (1.0 mmol for morpholine and aniline, 2.0 mmol for benzylamine, propargylamine and valine methyl ester hydrochloride, 3.1 mmol for tacn and tacd or 4.2 mmol for cyclam) was added in one portion with vigorous stirring. The reaction mixture was stirred for 1 h and evaporated in vacuo.Water (50 mL) was added to the residue and further purification was performed as following:For products 2a-d, 3-9: The precipitate was filtered off and washed with appropriate solvent (water for 2a-c, MeOH for 7-9, Et2O for 3-6, acetone for 2d) and dried with air.For products 2f,g: EtOAc (50 mL) was added, the organic extract was separated, washed with brine (50 mL), dried with Na2SO4and evaporated. The residue was purified by column chromatography on silica gel (hexane-EtOAc (5:1) ? EtOAc) to give products 2fand 2g.
4730-54-5, As the paragraph descriping shows that 4730-54-5 is playing an increasingly important role.
Reference£º
Article; Semakin, Artem N.; Kokuev, Aleksandr O.; Nelyubina, Yulia V.; Sukhorukov, Alexey Yu.; Zhmurov, Petr A.; Ioffe, Sema L.; Tartakovsky, Vladimir A.; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 2471 – 2477;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI