4730-54-5, 1,4,7-Triazacyclononane is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 1,4,7-triazonane (100 mg, 0.77 mmol, 1.0 eq) in DCM (2 mL, 20 vol) was cooled to 0-5 C. and added DIPEA (0.40 mL, 2.32 mmol, 3.0 eq) and Chloroacetyl chloride (0.18 mL, 2.32 mmol, 3.0 eq). The reaction mass was slowly warmed to 25-30 C. and stirred for 4 h. The progress of the reaction was monitored by TLC (10% methanol in DCM). After complete consumption of the 1,4,7-triazonane, water was added to the reaction mass and layers separated. The separated organic layer was evaporated under vacuum to get a syrupy mass. The crude product was purified through silica gel chromatography. 114 mg (60.0%) 1H NMR (400 MHz, CDCl3): delta 4.09 (s, 6H), 3.78 (t, 6H), 3.57 (t, 6H). Purity by LC-MS: 95.32%, RT: 1.33
4730-54-5, As the paragraph descriping shows that 4730-54-5 is playing an increasingly important role.
Reference£º
Patent; BicycleTx Limited; Beswick, Paul John; Ivanova-Berndt, Gabriela; Mudd, Gemma Elizabeth; Pavan, Silvia; Skynner, Michael; Teufel, Daniel Paul; Van Rietschoten, Katerine; (88 pag.)US2018/311300; (2018); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI