Application of 123-46-6, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.123-46-6, Name is Girards Reagent T, molecular formula is C5H14ClN3O. In a article£¬once mentioned of 123-46-6
Electron-deficient DNA-intercalating agents as antitumor drugs: Aza analogues of the experimental clinical agent N-[2- (dimethylamino)ethyl]acridine-4-carboxamide
A series of azaacridine (benzonaphthyridine) analogues of the drug N-[2- (dimethylamino)ethyl]acridine-4-carboxamide (DACA) (currently in clinical trial) were synthesized. These compounds showed DNA binding affinities similar to that of DACA, as determined by the fluorometric ethidium displacement assay, but were generally less potent cytotoxins against P388 leukemia in vitro. The only compounds showing higher cytotoxicity than DACA were analogues with nitro substituents at the (acridine) 1-position; by analogy with the 1-nitroacridine nitracrine, these compounds probably undergo reductive metabolism. The only azaacridine to show significant in vivo antileukemic activity was benzo[b] [1,5]nephthyridine-6-carboxamide. A possible reason for the unexpectedly low activity of these compounds (given the wide acceptability of substituents in DACA) may be their much lower lipophilicities, which are likely to result in lower rates of cell uptake.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 123-46-6, and how the biochemistry of the body works.Application of 123-46-6
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI