A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Application In Synthesis of Tetrapropylammonium bromide, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1941-30-6, Name is Tetrapropylammonium bromide, molecular formula is C12H28BrN. In a Article, authors is Jermy, B. Rabindran£¬once mentioned of 1941-30-6
Hierarchical mesosilicalite nanoformulation integrated with cisplatin exhibits target-specific efficient anticancer activity
Hierarchically structured zeolitic ZSM-5 and meso MCM-41 interlinked domain had an impeccable use as catalysis in many applications. The aim of the study was to develop a new drug delivery nanoformulation, specifically, cisplatin/mesosilicalite using top?down approach for cancer therapy. Hierarchical mesosilicalite with variable porosity was synthesized using alkaline molar solution (0.2 and 0.7?M NaOH) and was loaded with cisplatin through equilibrium adsorption technique. Physico-chemical properties of the nanoformulation (IAUM-56?Imam Abdulrahman Bin Faisal University Mesosilicalite-56) were characterized using X-ray diffraction, surface area analysis (BET), Fourier transformed infrared spectroscopy (FT-IR), diffuse reflectance UV?Vis spectroscopy, and transmission electron microscopy. Drug release study and anticancer activity were assayed on HeLa and MCF7 cancer cells using MTT assay. X-ray diffraction pattern showed interrelated meso- and microphases, while BET analysis revealed considerable mesoporosity formation with a remodulation of isotherm hysteresis indicating the presence of hierarchical pores. FT-IR showed the presence of nanozeolitic subunits into mesostructure with a band at about 550?cm?1. IAUM-56 demonstrated high cytotoxic activity against HeLa cancer cells with an LC50 of 0.02?mg/ml, MCF7 cancer cells with an LC50 of 0.05?mg/ml, and less toxic to normal fibroblast cells with an LC50 of approximately ten times higher at 0.5?mg/ml. Overall, IAUM-56 showed a high rate of sustained release of cisplatin imparting target specific cytotoxic effect against tumor cells with at least tenfold lower toxicity on normal fibroblast cells. Our nanoformulation has the potential use in cancer therapy as a targeted drug delivery system.
Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. Application In Synthesis of Tetrapropylammonium bromide
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI