A new application about 32780-06-6

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Wrona, Iwona E.; Garbada, Ana E.; Evano, Gwilherm; Panek, James S. published the article 《Total Synthesis of Reblastatin》. Keywords: reblastatin asym total synthesis hydrozirconation transmetalation aldehyde addition.They researched the compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one( cas:32780-06-6 ).Computed Properties of C5H8O3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:32780-06-6) here.

Enantioselective total synthesis of reblastatin is described. The synthesis highlights hydrozirconation, transmetalation, aldehyde addition sequence to install E-trisubstituted olefin and C7 stereocenter, and the first use of an intramol. Buchwald-like amidation reaction to close the 19-membered macrolactam.

Although many compounds look similar to this compound(32780-06-6)Computed Properties of C5H8O3, numerous studies have shown that this compound(SMILES:O=C1O[C@H](CO)CC1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI