One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 80875-98-5, Name is H-Oic-OH, formurla is C9H15NO2. In a document, author is Babu, Gogu V. Surendra, introducing its new discovery. Computed Properties of C9H15NO2.
Ullmann Coupling Reaction of Bicyclic Amidines DBU/DBN with Aryl Halides: A Pathway to the Synthesis of epsilon-Caprolactam Derivatives
This paper demonstrates a selective, mild approach to Ullmann amination of aryl halides to synthesize N-alkylated derivatives of epsilon-caprolactam. The synthetic route involves an in-situ ring-opening of 1,8-diazabicyclo[5.4.0]undec-8-ene (DBU) followed by concurrent arylation with aryl halides in the presence of copper iodide as a catalyst under ligand-free conditions. This method provides a new entry to a wide variety of epsilon-caprolactam derivatives in good to excellent yields in a single synthetic sequence. Similarly, other bicyclic amidines such as 1, 5-diazabicyclo-[4.3.0]non-5-ene (DBN), and 1,5,7 triazabicyclo[4.4.0] dec-5-ene (TBD) also showed good to very high reactivity. Azepan-2-one, or Caprolactam, is an important synthon in polymer chemistry and has a global demand as it is employed to make Nylon 6 filament, fiber, and plastics.([1]) The global caprolactam market size is expected to expand for the growing textile industry with rising demand for plastics in the construction of automotive, electrical, and electronic sectors. Additionally, technological advancements aimed at improving the cost-effective manufacturing process of caprolactam, to minimize the release of hazardous waste into the environment is of vital necessity. Derivatives of epsilon-caprolactam are of interest for the production of modified nylons([2]) and nanogels.([3]) Several Azepinones and their analogs play an important role in medicinal chemistry,([4]) used in the synthesis of pharmaceutical drugs including Benazepril,([5]) Telcagepant,([6]) and Ivabradine.([7])
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Reference:
Metal catalyst and ligand design,
,Ligand Template Strategies for Catalyst Encapsulation – NCBI