10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step-2: Preparation of tetrabutylammonium salt of (2,S’,5ii)-2-[(6-sulfooxy-7-oxo-l,6- diaza-bicyclo[3.2.1]octane-2-carbonyl)-methyloxycarbamoyl]-(2,S’)-pyrrolidine-l- carboxylic acid tert-butyl ester: A solution of the Benzyl compound (2.1g, mmol) in 1: 1 mixture of DMF: DCM (5ml), was hydrogenated over 10% Pd/C (125mg) over 1 atmosphere of Hydrogen balloon. After stirring for 4 hours the reaction mixture was filtered over celite. The filtrate was concentrated under reduced pressure and the residue obtained was dissolved in fresh DMF (2.5ml) and cooled to 10C.SO3.DMF complex (193mg, 12.6mmol) was added and the reaction mixture was allowed to warm to RT. After stirring RM at RT for 1.5 hours, TBAA (379mg, 12.6mmol) in water (1.25ml) was added to the reaction mixture and stirring continued further for 2hours. The volatiles were removed by high vacuum distillation and the residue co-evaporated with xylene (2X25ml) to remove traces of DMF. The residue obtained was diluted with water (20ml) and extracted with DCM (3X20ml). The combined DCM layer was washed with water (2X20ml). The DCM layer was dried and the solvent evaporated under reduced pressure. The crude residue was triturated with Diethyl ether (3X25ml) to obtain the product as a white solid, 610mg, 82% yield. Analysis: Mass: 463.4 (M-H) for MW-705.96 and M.F- C33H63N509 S. XH NMR: Solvent(CDCl3): 10.2 (s, 1H), 4.35 (s, 1H), 4.14 (s, 1H), 3.91-3.92 (d, 2H), 3.74 (m, 1H), 3.36-3.27 (m, 10H), 2.96-2.88 (dd, 2H), 2.31-2.26 (m, 2H), 2.19-1.98 (m, 2H), 1.95-1.70 (m, 4H), 1.68-1.62 (p, 8H), 1.49-1.40 (m, 17H), 1.02-0.98 (t, 12H) .
As the paragraph descriping shows that 10534-59-5 is playing an increasingly important role.
Reference£º
Patent; WOCKHARDT LIMITED; PATIL, Vijaykumar, Jagdishwar; TADIPARTHI, Ravikumar; DOND, Bharat; KALE, Amol; VELUPILLAI, Loganathan; DEKHANE, Deepak; BIRAJDAR, Satish, Shrimant; SHAIKH, Mohammad, Usman; MAURYA, Sushilkumar; PATEL, Piyush, Ambalal; DIXIT, Prasad; PAWAR, Mangesh; PATEL, Mahesh, Vithalbhai; BHAGWAT, Sachin; WO2014/33560; (2014); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI