Analyzing the synthesis route of 130-95-0

130-95-0 Quinine 3034034, acatalyst-ligand compound, is more and more widely used in various fields.

130-95-0, Quinine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example: 11a-(-)-3-(Carbamoylmethyl)-5-methylhexanoic Acid Quinine Salt Aqueous acetone (795ml) was added to the amide II (53 g, 283.42 mmole) at room temperature and the reaction mixture was heated until it became homogenous. Quinine (91 .8 g, 283.42 mmole) was added to the mixture at 80 C. After 15 minutes at this temperature, another batch of quinine (5.3 g, 28.34 mmole) was added to the reaction mixture and heating was continued until the mixture became homogenous. The reaction mixture was allowed to cool down to room temperature. The precipitated solid was filtered, dried and purified to furnish the diastereoisomeric salt of the amide I as a solid which was broken down to obtain enantiomerically enriched amide I; yield: 18 g; 67.9%; HPLC purity: 99.97%., 130-95-0

130-95-0 Quinine 3034034, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Dr. Braja Sundar Pradhan; WO2012/93411; (2012); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI