Analyzing the synthesis route of 13910-48-0

13910-48-0, 13910-48-0 N1-Benzylpropane-1,3-diamine 83811, acatalyst-ligand compound, is more and more widely used in various fields.

13910-48-0, N1-Benzylpropane-1,3-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Pyrazolone 1b (643 mg, 1.88 mmol) was dissolved in CH3CN (10 mL) and amine 2N-benzylpropane-1,3-diamine was added at 0 C under N2. The reaction mixture was stirred at 0 C for 3 h and monitored by LC-MS showing 40% of starting material left. Then DIPEA (two drops) was added and the mixture was stirred at RT for 1 h: LC-MS showed completely conversion of starting material into desired product. The solvent was concentrated in vacuo until dryness. The residue was dissolved in ethylacetate (10 mL), washed with saturated NaHCO3 solution (5 mL * 2), dried over Na2SO4 and concentrated. The crude product was used in the following step without further manipulation (530 mg, 71% yield, 86% HPLC purity, LC-MS (M+H)+: 453.4).

13910-48-0, 13910-48-0 N1-Benzylpropane-1,3-diamine 83811, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Gaggini, Francesca; Laleu, Benoit; Orchard, Mike; Fioraso-Cartier, Laetitia; Cagnon, Laurne; Houngninou-Molango, Sophie; Gradia, Angelo; Duboux, Guillaume; Merlot, Cedric; Heitz, Freddy; Szyndralewiez, Cedric; Page, Patrick; Bioorganic and Medicinal Chemistry; vol. 19; 23; (2011); p. 6989 – 6999;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI