4568-71-2, 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(2) beta-(4-Fluorophenyl)-alpha-(2-methyl-1-oxopropyl)-gamma-oxobenzenebutanoic acid, ethyl ester A mixture of Part (1) compound (14.59 g, 55.4 mmoles), 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride (4.484 g, 0.3 eq.) and triethylamine (5.4 mL, 0.7 eq.) was treated with benzaldehyde (1.9 mL), heated up to 70¡ã (oil bath) under argon and stirred at 70¡ã for 1.0 hour. The addition of benzaldehyde was repeated three more times (1.9 mL each), heating the mixture for 1.0 hour after each addition. The reaction mixture was cooled down to room temperature, diluted with ethyl acetate (800 mL) and washed successively with 5percent KHSO4 (150 mL), saturated sodium bicarbonate (150 mL) and brine (150 mL). The organic solution was dried (anhydrous MgSO4), filtered, evaporated to dryness and dried in vacuo . The crude product was combined with previous runs (881.6 mg and 236.5 mg) and chromatographed on a silica gel column (Merck), eluding the column with Et2O:Hexane mixtures (5:95; 1:9) to give title compound as a light yellow thick syrup (20.694 g, 98.3percent). TLC: Rf0.22 (Silica gel; Et2O:Hexane- 15:85; UV).
As the paragraph descriping shows that 4568-71-2 is playing an increasingly important role.
Reference£º
Patent; E.R. SQUIBB & SONS, INC.; EP463456; (1992); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI