62937-45-5, D-Prolinamide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 7: 1-r(3-(6-Methyl-4-r(3.3.3-trifluoro-2-m(4-fluorophenvnsulfonylU1- methylethv?aminolmethyl’y-2-hvdroxypropy?aminol-1/-/-indazol-1-yl)phenv?carbonyl1- D-prolinamide; lambda/,lambda/-Diisopropylethylamine (0.0644mL) and HATU (29.5mg) were added to a solution of 3-(4-{[2-({ethyl[(4-fluorophenyl)sulfonyl]amino}methyl)-3,3,3-trifluoro-2- hydroxypropyl]amino}-6-methyl-1/-/-indazol-1-yl)benzoic acid (45mg, 0.074mmol) in DMF (1.4mL) and the mixture stirred at room temperature under for 10 min. D- Prolinamide (21.1 mg) was then added and the mixture stirred at room temperature overnight. More D-prolinamide was added and the mixture stirred for a further 24 hours and then diluted slightly with methanol and purified by mass directed autopreparation (System B). Product containing fractions were combined and partitioned between dichloromethane and saturated aqueous sodium bicarbonate. The aqueous phase was re-extracted with dichloromethane and the combined organic extracts were washed successively with water and brine, dried through a hydrophobic frit and evaporated to give the title compound (22.2mg). LCMS: tRET = 3.38 min; MH+ = 70519mg of this mixture of diastereomers was resolved by chiral HPLC on a 2 x 25cm Chiralpak AD column eluted with heptane : iso-propanol 1 : 1 with a flow rate of 15 mL/min to provide Example 7-A (diastereomer A, 6.5mg) and Example 7-B (diastereomer B, 7.5mg).Example 7-A (diastereomer A): Analytical chiral HPLC (25 x 0.46 cm Chiralpak AD column, heptane : iso-propanol 1 : 1 eluting at 1 mL/min): tREtau = 8.6 min LCMS: tRET = 3.41 min; MH+ = 705Example 7-B (diastereomer B): Analytical chiral HPLC (25 x 0.46 cm Chiralpak AD column, heptane : iso-propanol 1 : 1 eluting at 1 mL/min): tREtau = 11.6 min
As the paragraph descriping shows that 62937-45-5 is playing an increasingly important role.
Reference£º
Patent; GLAXO GROUP LIMITED; WO2009/50218; (2009); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI