With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.787-70-2,[1,1′-Biphenyl]-4,4′-dicarboxylic acid,as a common compound, the synthetic route is as follows.
Weigh 4,4′-biphthalic acid (10.00g, 41.3mmol) and silver sulfate (28.00g, 89.7mmol) into a 500mL double-necked flask, then add 250mL concentrated sulfuric acid and at room temperature Stir, then weigh the iodine element (23.00g, 90.5mmol) and add it to the double-necked flask, and cover the double-necked flask with tin foil for light-shielding treatment. The reaction takes place at room temperature for 1 hour, then the temperature is raised to 80 C, and the reaction is continued for 24 hours . After the reaction was completed, the reaction solution was cooled to room temperature, and the reaction solution in the double-necked flask was poured into 500 mL of ice water, resulting in a large amount of yellow precipitate, and the crude product was obtained by filtration. The above crude product was added to a 500 mL single-necked flask, and 300 mL of methanol was added. After stirring, 5 mL of concentrated sulfuric acid was slowly added dropwise, the temperature was raised to 100 C, the reaction was refluxed for 12 hours, cooled to room temperature, and the organic solvent was distilled off under reduced pressure. Saturated brine, and extracted three times with 500 mL of dichloromethane. The organic phase was dried over anhydrous magnesium sulfate, and the organic solvent was distilled off under reduced pressure. The organic solvent was purified by chromatography using methylene chloride as the eluent. 18.35 g of dimethyl ‘-diiodo-4,4’-diphthalate, that is, compound a, with a yield of 85.1% (based on dimethyl diphthalate)., 787-70-2
787-70-2 [1,1′-Biphenyl]-4,4′-dicarboxylic acid 13084, acatalyst-ligand compound, is more and more widely used in various fields.
Reference£º
Patent; Tongji University; Zhang Ronghua; Liu Changwei; Li Liangchun; (9 pag.)CN110483333; (2019); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI