In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 144222-34-4, name is N-((1R,2R)-2-Amino-1,2-diphenylethyl)-4-methylbenzenesulfonamide, introducing its new discovery. Application In Synthesis of N-((1R,2R)-2-Amino-1,2-diphenylethyl)-4-methylbenzenesulfonamide
Biphasic glycerol/2-MeTHF, ruthenium-catalysed enantioselective transfer hydrogenation of ketones using sodium hypophosphite as hydrogen donor
Sodium hypophosphite has been used as an efficient hydrogen donor in the transfer hydrogenation of aliphatic and aromatic ketones in the presence of [RuCl2(p-cymene)]2 and 2,2?-bipyridine in water. The corresponding alcohols were isolated in moderate to excellent yields (39-95 %). Good chemoselectivity was observed with ester, nitrile and halide functionalities in the ketones not being reduced. An enantioselective version of the reaction using [RuCl(p-cymene){(R,R)-TsDPEN}] as catalyst in a glycerol/2-MeTHF biphasic solvent mixture has been developed and allowed the reduction of (hetero)aromatic ketones with excellent chemo- and enantioselectivities (up to 97 % ee). Sodium hypophosphite has been used in the reduction of ketones in water (nine examples, 40-95 % yield). An original glycerol/2-MeTHF biphasic solvent system has been developed for the enantioselective version of the reaction. This system allows the preparation of aryl alkyl alcohols with up to 97 % ee (22 examples). Copyright
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 144222-34-4 is helpful to your research. Application In Synthesis of N-((1R,2R)-2-Amino-1,2-diphenylethyl)-4-methylbenzenesulfonamide
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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI