A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, SDS of cas: 91804-75-0, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 91804-75-0, Name is 1,10-Phenanthroline-5-carbaldehyde, molecular formula is C13H8N2O. In a Article, authors is Ma, Wenli£¬once mentioned of 91804-75-0
Four bichromophoric cyclometalated iridium complexes were synthesized and fully characterized. Their antiproliferative capacity against A549, HepG2 cells and HeLa cells as well as two human normal cells was studied by MTT assay. Rhodamine B modified complexes 2 and 4 were not cytotoxic to A549 cells while both rhodamine 6 g modified complexes 1 and 3 showed greater cytotoxicity than cisplatin. In particular, the antiproliferative activity of complex 3 was about 4.6 times than that of cisplatin. Thus, complex 3 was used for stability and pH sensitivity studies. The results indicated that the complex not only had rich fluorescence properties under acidic conditions, but also showed good stability. Further, interaction of complex with bovine serum albumin (BSA) has been investigated by UV?vis, fluorescence, synchronous fluorescence spectroscopy. The complexes have a certain ability to bind the BSA. Interestingly, these complexes can catalyze the reaction of the coenzyme NADH to NAD+, which is consistent with the apparent growth of ROS in cells. In addition, complex 3 can cause S phase arrest in the cell cycle, induce apoptosis, and affect mitochondrial membrane potential changes. Localization experiments of intracellular complexes by confocal microscopy suggested that these complexes enter cancer cells through energy dependence and specifically target the lysosomes, thus resulting in the damage of lysosomes.
Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. SDS of cas: 91804-75-0
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI