Synthetic Route of 148461-14-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.148461-14-7, Name is (S)-2-(2-(Diphenylphosphino)phenyl)-4-isopropyl-4,5-dihydrooxazole, molecular formula is C24H24NOP. In a Article£¬once mentioned of 148461-14-7
Cu(I)-Ming-phos Catalyzed Enantioselective [3+2] Cycloadditions of Glycine ketimines to beta-Trifluoromethyl Enones
A catalytic asymmetric [3+2] cycloaddition of glycine ketimines with beta-CF3 beta,beta-disubstituted enones was realized in the presence of a chiral copper(I)/Ming-Phos complex. This method provides an access to construct highly functionalized pyrrolidines bearing three contiguous stereocenters, which including a trifluoromethylated all-carbon quaternary stereocenter. The features of this reaction include high chemo-, diastereo-, enantioselectivity (up to >20:1 cr, >20:1 dr, 98% ee), readily available starting materials, well functional-group tolerance and mild reaction conditions. Control experiments demonstrate that the fluoro-substituent is crucial for the reactivity. (Figure presented.).
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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI