Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ category: catalyst-ligand, Which mentioned a new discovery about 18741-85-0
Chiral cobalt-catalyzed enantiomer-differentiating oxidation of racemic benzoins by using molecular oxygen as stoichiometric oxidant
A study was conducted to demonstrate chiral cobalt-catalyzed enantiomer-differentiating oxidation of racemic benzoins using molecular oxygen as stoichiometric oxidant. The cobalt-catalyzed asymmetric oxidation was performed with racemic benzoins due to their importance in pharmaceutical industry and difficulty in synthesizing them in enantiomerically pure form. The investigation was conducted with (¡À)-4-methoxy benzoin as model substrate for oxidative kinetic resolution. The oxidation took 7 d for 44% conversion and provided 41% of 4-methoxy benzil when (¡À)-4-methoxy benzoin was reacted with 5 mol% of TEMPO and 5 mol% of enantiopure (L)-proline-Co(OAc)2 complex in the presence of molecular oxygen at room temperature. It was observed that 52% of 4-methoxy benzoin was recovered with 4% enantiomeric excess and selectivity in the asymmetric oxidation reaction.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, category: catalyst-ligand, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 18741-85-0
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI