With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.114527-28-5,4-(4′-Methyl-[2,2′-bipyridin]-4-yl)butanoic acid,as a common compound, the synthetic route is as follows.
General procedure: Prepared from 15 mg scale reactions with the Ru(dppz)(bpy?-CO2CH3)2Cl2 complex described above. The bis-ligated starting material was massed dry on paper and transferred to a 10 mL schlenck bulb flask along with one equivalent of bpy?-CO2CH3 (Complex 7) or bpy?-CO2H (Complex 8), both transferred as oils. Reactions involved refluxing approximately 4 mL 1:1 ethanol:water for 36-48 h with vigorous stilling under the protection of nitrogen and in low light conditions. The work up for these reactions followed general procedures. (73% yield for Complex 7; 85% yield for Complex 8)
114527-28-5, The synthetic route of 114527-28-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NORTHWESTERN UNIVERSITY; Mirkin, Chad A.; Shade, Chad M.; Kennedy, Robert D.; Rouge, Jessica Lynn; Seo, Soyoung E.; Wang, Mary X.; (17 pag.)US9969759; (2018); B2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI