Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， HPLC of Formula: C11H12N2O2, Which mentioned a new discovery about 153-94-6
A new method is described for the determination of optical purity of alpha-amino acid samples in protic media. No derivatization of the analyte or multistep synthesis is required, and high accuracy is obtained from the colorimetric output. Chiral discrimination is achieved through the use of an optically pure trans-1,2-diaminocyclohexane-derived Cu(II)-containing host that differentiates amino acid enantiomers by a factor of about 2. Enantioselective signaling arises from the implementation of an indicator displacement assay based on competitive Cu(II) coordination involving the chiral Cu(II)-containing host, the amino acid guest, and a metal ion indicator. The molecular structure of the host/guest complex was determined by X-ray analysis and exhibits chelation of the Cu(II) center by the amino acid to provide substrate organization. Copyright
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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI