162318-34-5, 5-Ethynyl-2,2′-bipyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
For the cross-coupling reaction leading to 5-ethynyl-2,2?-bipyridine (0.150 g, 0.83 mmol), the 5-bromo-2,2?-bipyridine (0.200 g, 0.83 mmol) was dissolved in benzene at 80 C. When a clear solution was obtained, [Pd(PPh3)4] (0.092 g, 0.08 mmol) and 5 mL of triethylamine were added. After 24 h of heating at 80 C, the solvent was removed under vacuum and the residue was purified by flash column chromatography (silica gel, MeOH/CH2Cl2 = 1/9). Yield: 48% (133 mg), TLC (SiO2): Rf 0.28 (10% methanol/dichloromethane); IR (KBr, cm-1) 3053 (Ar-H), 3008 (Ar-H), 2923 (Ar-H), 2850 (Ar-H), 1456 (aromatic C=C), 798 (Ar-C), 1H NMR (400 MHz, CDCl3) delta 7.32-7.35 (m, 2H, PyH), 7.82-7.86 (m, 2H, PyH), 7.97-8.00 (m, 2H, PyH), 8.43-8.46 (m, 4H, PyH), 8.70-8.71 (m, 2H, PyH), 8.85-8.86 (m, 2H, PyH); HRMS: m/z calc. for C22H14N4: calc. for 336.1375, found 336.1369., 162318-34-5
The synthetic route of 162318-34-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Kim, Minki; Kang, Chang Hoon; Hong, Subong; Lee, Won-Yong; Kim, Byeong Hyo; Inorganica Chimica Acta; vol. 395; (2013); p. 145 – 150;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI