170161-27-0, Tri-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of tri-Boc cyclam S7 (437 mg, 0.873 mmol) in anhydrous CH3CN (26 mL)were added Na2CO3 (370 mg, 3.49 mmol) and propargyl bromide (-80% in toluene, 156pL, 1 .05 mmol). The reaction mixture was heated at reflux under N2 overnight. Theinsoluble salts were filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by flash column chromatography (silica gel, EtOAc:hexane =7:3) to give S11 as a white foam (446 mg, 95%). RF (EtOAc:hexane = 7:3) 0.58. m.p.47-48 C (lit.45?66 m.p. 4749 C). IR Vmax/cm1 3305, 3243, 2976, 2932, 2871, 2826,1681, 1463, 1410, 1365, 1240, 1150. 1H NMR (200 MHz, CDCI3) 5 1.40 (5, 27H, 3 xC(CH), 1.55-1.75 (m, 2H, CH2CH2CH2), 1.75-1.95 (m, 2H, CH2CH2CH2), 2.12 (5, 1H,CCH), 2.46 (t, 2H, J 5.4, CH2N(CH2CCH)CH2), 2.55-2.70 (m, 2H, CH2N(CH2CCH)CH2), 3.10-3.50 (br m, 14H, 3 x CH2N(Boc)CH2 & NCH2CCH). MS (ESI) m/z539.4 ([M+H], 100%), 561.5 ([M+Na], 28%). The spectroscopic data were inagreement with those in the literature.25?26, 170161-27-0
170161-27-0 Tri-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate 10940041, acatalyst-ligand compound, is more and more widely used in various fields.
Reference£º
Patent; THE UNIVERSITY OF SYDNEY; RUTLEDGE, Peter; TODD, Matthew; TRICCAS, James Anthony; WO2014/153624; (2014); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI