With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23616-79-7,N-Benzyl-N,N-dibutylbutan-1-aminium chloride,as a common compound, the synthetic route is as follows.
EXAMPLE 3 A 3-necked, 250 mL round-bottomed flask equipped with a reflux condenser and two pressure equalizing addition funnels was charged with 60 mL of a 30 percent by weight aqueous sodium hydroxide solution and 1.275 gram (4.1 mmol) of benzyltributylammonium chloride. 4-hydroxymethyl-2-methoxy-2-methyl-1,3-dioxolane (29.14 g, 196.7 mmol) and 25 g vinylbenzyl chloride (164 mmol) were simultaneously charged under a nitrogen atmosphere from the addition funnels into the flask over a 5 minute period. The reaction flask was immersed in an oil bath at 50 C. and the contents were stirred for 6 hours, then stirred at room temperature overnight. The organic phase was separated, diluted with methylene chloride (200 mL) and triethylamine (5 mL), washed with water, dried over anhydrous magnesium sulfate, and vacuum stripped. 42 g of 4-hydroxymethyl-2-methoxy-2-methyl-1,3-dioxolane vinylbenzyl ether were produced.
23616-79-7, 23616-79-7 N-Benzyl-N,N-dibutylbutan-1-aminium chloride 159952, acatalyst-ligand compound, is more and more widely used in various fields.
Reference£º
Patent; General Electric Company; US5231197; (1993); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI