So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Peru, Aurelien A. M.; Flourat, Amandine L.; Gunawan, Christian; Raverty, Warwick; Jevric, Martyn; Greatrex, Ben W.; Allais, Florent researched the compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one( cas:32780-06-6 ).Formula: C5H8O3.They published the article 《Chemo-enzymatic synthesis of chiral epoxides ethyl and methyl (S)-3-(oxiran-2-yl)propanoates from renewable levoglucosenone: an access to enantiopure (S)-dairy lactone》 about this compound( cas:32780-06-6 ) in Molecules. Keywords: levoglucosenone Baeyer Villiger oxidation acid hydrolysis hydrogenation; butyrolactone preparation green chem; octenyl tetrahydrofuranone preparation green chem; chirality; epoxide; flavor; levoglucosenone; total synthesis. We’ll tell you more about this compound (cas:32780-06-6).
Herein, starting from levoglucosenone (LGO), a biobased chiral compound was obtained through the flash pyrolysis of acidified cellulose, a safer and more sustainable chemo-enzymic synthetic pathway involving lipase-mediated Baeyer-Villiger oxidation, palladium-catalyzed hydrogenation, tosylation and treatment with sodium ethoxide/methoxide as key steps was proposed. This route afforded Et and Me (S)-3-(oxiran-2-yl)propanoates in 57% overall yield, resp. To demonstrate the potentiality of this new synthetic pathway from LGO, the synthesis of high value-added (S)-dairy lactone was undertaken from these epoxides and provided the target in 37% overall yield from LGO.
Although many compounds look similar to this compound(32780-06-6)Formula: C5H8O3, numerous studies have shown that this compound(SMILES:O=C1O[C@H](CO)CC1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI