Synthetic Route of C5H6O2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5,6-Dihydro-2H-pyran-2-one, is researched, Molecular C5H6O2, CAS is 3393-45-1, about Alkylidene Meldrum’s Acids as Platforms for the Vinylogous Synthesis of Dihydropyranones. Author is Wittmann, Stephane; Martzel, Thomas; Pham Truong, Cong Thanh; Toffano, Martial; Oudeyer, Sylvain; Guillot, Regis; Bournaud, Chloee; Gandon, Vincent; Briere, Jean-Francois; Vo-Thanh, Giang.
Upon Broensted base organocatalysis, ketone-derived alkylidene Meldrum’s acids proved to be competent vinylogous platforms able to undergo a formal (4+2) cycloaddition reaction with dihydro-2,3-furandione, providing an unprecedented route to 3,6-dihydropyran-2-ones as spiro[4.5]decane derivatives, e.g., I, with up to 98% ee thanks to the com. available Takemoto catalyst. Preliminary investigation showed that this reaction could be extended to other activated ketones, establishing these alkylidene Meldrum’s acids as a novel C4-synthon in the vinylogous series.
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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI