With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4199-88-6,5-Nitro-1,10-phenanthroline,as a common compound, the synthetic route is as follows.
Complex 1 was prepared by a conventional synthetic method, in which a mixture ofdichloromethane and methanol (42 mL, 2:1) was added to a flask containing [Ir(Hppy)2Cl]2 (0.323 g,0.30 mmol) and NP (0.135 g, 0.60 mmol) [19]. The mixture was refluxed for 6 h under argon to givea red brown solution. After cooling, a bright red precipitate was obtained by dropwise additionof concentrated NH4PF6 aqueous solution with stirring at room temperature for 2 h. The crudeproduct was purified by column chromatography on alumina eluted with dichloromethane-acetone(1:3, v/v). The red band was collected, the solvent was evaporated under the reduced pressure, and abrown-yellow powder was obtained. Yield: 86%. Anal. Calc for C34H23F6N5O2PIr: C, 46.90; H, 2.66;N, 8.04%. Found: C, 46.81; H, 2.72; N, 8.12%. 1H NMR (500 MHz, DMSO-d6): 9.46 (s, 1H), 9.20 (d, 1H,J = 8.0 Hz), 9.12 (d, 1H, J = 7.5 Hz), 8.34 (dd, 2H, J = 5.5, J = 6.0 Hz), 8.26 (d, 2H, J = 8.0 Hz), 8.19-8.15(m, 2H), 7.95 (d, 2H, J = 8.0 Hz), 7.88 (t, 2H, J = 7.5 Hz), 7.52 (dd, 2H, J = 6.0, J = 6.0 Hz), 7.06 (t, 2H,J = 7.5 Hz), 7.01-6.94 (m, 5H), 6.26 (d, 2H, J = 7.5 Hz). 13C NMR (125 Hz, DMSO-d6): 166.70, 153.41,151.88, 149.56, 149.11, 147.87, 146.79, 144.96, 144.04, 140.80, 138.87, 135.24, 131.23, 130.33, 128.52, 128.34,127.45, 125.14, 123.97, 123.89, 122.60, 120.03. ESI-MS (CH3CN): m/z 725.9 ([M-PF6]+)., 4199-88-6
As the paragraph descriping shows that 4199-88-6 is playing an increasingly important role.
Reference£º
Article; Zhang, Li-Xia; Gu, Yi-Ying; Wang, Yang-Jie; Bai, Lan; Du, Fan; Zhang, Wen-Yao; He, Miao; Liu, Yun-Jun; Chen, Yan-Zhong; Molecules; vol. 24; 17; (2019);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI