With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.56-41-7,H-Ala-OH,as a common compound, the synthetic route is as follows.
The L-alanine was used as substrate to produce (S)-alanine methyl ester hydrochloride (1a) according to the literature. (Xing et al., 2012). Add 15 mL of absolute methanol to the round bottom flask. Slow-drop 2.16 mL of SOCl2 (0.03 mol) into absolute methanol at -15 C and maintained at 0 C for an hour. Take 14 mL of absolute methanol and 1.4 mL (0.019 mol) of SOCl2 to another round bottom flask with the above steps. Then, 1.118 g of L-alanine were put into the solution and heating reflux for 1.5 h. After concentrated the solution under reduced pressure, the initial preparation of the SOCl2 solution was poured into the round bottom flask and continued reflux for 1.5 h to give 1a (yield 100%). Since the hydrochloric acid produced in this step was not conducive to the next reaction, put NaHCO3 into the round bottom flask when reflux was ended to destroy its acidity until no more bubbles are generated. Finally, the solution was concentrated to afford 1b (yield 100%).The fusaric acid (4) and 1b together with 15 mL of dichloromethane were put into a round bottom flask and stirred uniformly, then an excessof catalyst dicyclohexylcarbodiimide (DCC) and 4-dimethylaminopyridine (DMAP) were added and reflux for 24 h. Concentrated the solution under reduced pressure and the product was purified by using preparative HPLC (25-45% CH3CN/H2O, 20 min) to obtain 1c (yield 52%).
As the paragraph descriping shows that 56-41-7 is playing an increasingly important role.
Reference£º
Article; Zhang, Pei-liang; Wang, Gang; Liu, Jin-song; Xu, Feng-qing; Zhao, Zhen-zhu; Wang, Wen-xiang; Wang, Ju-tao; Wang, Guo-kai; Wu, Pei-yun; Phytochemistry Letters; vol. 26; (2018); p. 50 – 54;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI