A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Safety of 6-Bromo-2,2′-bipyridine, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 10495-73-5, Name is 6-Bromo-2,2′-bipyridine, molecular formula is C10H7BrN2. In a Article, authors is Joubert, Nicolas£¬once mentioned of 10495-73-5
Modular and practical synthesis of 6-substituted pyridin-3-yl C-nucleosides
(Chemical Equation Presented) A novel modular and practical methodology for preparation of 6-substituted pyridin-3-yl C-nucleosides was developed. The Heck reaction of 2-chloro-5-iodopyridine with a 3?-TBDMS-protected glycal gave a 6-chloropyridin-3-yl nucleoside analogue, which was then desilylated, selectively reduced, and reprotected to give the TBDMS-protected 6-chloropyridin-3-yl C-2?-deoxyribonucleoside as a pure beta-anomer in a total yield of 39% over four steps. This key intermediate was then subjected to a series of palladium-catalyzed cross-coupling reactions, aminations, and alkoxylations to give a series of protected 1beta-(6-alkyl-, 6-aryl-, 6-hetaryl, 6-amino-, and 6-tert-butoxypyridin-3-yl)-2?- deoxyribonucleosides. 6-Unsubstituted pyridin-3-yl C-nucleoside was prepared by catalytic hydrogenation of the chloro derivative and 6-oxopyridine C-nucleoside by treatment of the 6-tert-butoxy derivative with TFA. Deprotection of all the silylated nucleosides by Et3N¡¤3HF gave a series of free C-nucleosides (10 examples).
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 10495-73-5, help many people in the next few years.Safety of 6-Bromo-2,2′-bipyridine
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI