With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62937-45-5,D-Prolinamide,as a common compound, the synthetic route is as follows.
62937-45-5, 4,6-dichloro-2-pyrimidinamine (656 mg, 4.00 mmol) and D-prolinamide (457 mg, 4 mmol) were dissolved in 10 mL of acetonitrile, diethylaminomethyl-polystyrene (3000 mg, 9.60 mmol) was added and the contents were heated in the microwave at 160 C for 1 hr. By LCMS, reaction seems to be complete (no SM). The contents were filtered to remove the polystyrene base, rinsed with acetonitrile and the mother liquor and washings rotovapped to dryness. The crude material was briefly triturated with diethyl ether, sonicated and decanted, and dried by vacuum to give the title compound (690 mg). LC-MS (ES) m/z = 242 [M+H]+.
As the paragraph descriping shows that 62937-45-5 is playing an increasingly important role.
Reference£º
Patent; GLAXOSMITHKLINE LLC; AXTEN, Jeffrey, Michael; BRADY, Gerald, Patrick, Jr.; GALLAGHER, Timothy, Francis; HEERDING, Dirk, A.; MEDINA, Jesus, Raul; ROMERIL, Stuart, Paul; WO2010/120854; (2010); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI