With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6813-38-3,[2,2′-Bipyridine]-4,4′-dicarboxylic acid,as a common compound, the synthetic route is as follows.,6813-38-3
Weigh 4,4′-dicarboxy-2,2′-bipyridine 500mg (2.05mmol) was added to the reaction flask, 100mL of methanol was added, 8mL of concentrated sulfuric acid was slowly added dropwise and stirred at 105 for 12h. After the reaction was completed and cooled to room temperature, the reaction was added to 500 mL of water, and the pH was adjusted to 9 using saturated NaOH solution. After the pH was adjusted, 200 mL of dichloromethane solution was added and allowed to stand still. At this time, a white flocculent precipitate was formed and the supernatant was poured out. The lower layer was extracted with dichloromethane and water (3 ¡Á 100 mL), the organic phase was extracted and dried to give the product , Yield 76%.
As the paragraph descriping shows that 6813-38-3 is playing an increasingly important role.
Reference£º
Patent; Nanjing University of Posts and Telecommunications; Zhang Yin; Zhang Taiwei; Sun Guanglan; Gao Pengli; Chen Xiaojiao; Zhao Qiang; Liu Shujuan; Huang Wei; (16 pag.)CN107417737; (2017); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI