The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine( cas:89972-77-0 ) is researched.Application In Synthesis of 4-(p-Tolyl)-2,2:6,2-terpyridine.Wang, Xiao-xia; Liu, Han-guo; Wan, Xia; Yin, Xia; Zhou, Fu-shan; Wu, Jian-zhong published the article 《Synthesis of 4-tolyl-2,2′:6′,2”-terpyridine》 about this compound( cas:89972-77-0 ) in Huaxue Shiji. Keywords: methylphenyl terpyridine preparation cyclization. Let’s learn more about this compound (cas:89972-77-0).
3-(4-Methylphenyl)-1,5-di(2-pyridinyl)-1,5-pentanedione was prepared by reaction of 2-acetylpyridine with 4-methylbenzaldehyde at room temperature using ethanol as the solvent. Treatment of the latter compound with concentrated ammonia for 1 h in the presence of sodium hydroxide gave the title compound [i.e., 4′-(4-methylphenyl)-2,2′:6′,2”-terpyridine] in 31.7% yield. The above reaction conditions were mild and the products could be purified easily.
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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI