Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Phytochemistry (Elsevier) called Alkaloid chemophenetics and transcriptomics of the Nicotiana genus, Author is Kaminski, Kacper Piotr; Bovet, Lucien; Laparra, Helene; Lang, Gerhard; De Palo, Damien; Sierro, Nicolas; Goepfert, Simon; Ivanov, Nikolai V., which mentions a compound: 494-52-0, SMILESS is C1(C=NC=CC=1)[C@@H]1CCCCN1, Molecular C10H14N2, Product Details of 494-52-0.
In this study, we determined the pyridine alkaloid content (nicotine, nornicotine, anabasine, anatabine, cotinine, and myosmine) of 58 species and 2 subspecies of the Nicotiana genus by ultra-high-performance liquid chromatog. coupled with mass spectrometry. We observed clear correlation between Noctiflorae and Suaveolentes sections and their above average accumulation of anabasine in genus. In addition, the results demonstrated the presence of not only trace amounts but quantifiable levels of myosmine, an alkaloid previously detected in only minute quantities, in leaves and roots of 16 species. Anal. of gene expression of 58 species and 2 subspecies from Nicotiana genus by mRNA sequencing was performed for first time. Sequencing reads were mapped against annotated genes of N.tabacum reference genome and expression values were subsequently calculated Hierarchical clustering of alkaloid biosynthesis pathway genes and alkaloid content composition revealed patterns clearly segregating Nicotiana sections. Correlation of gene expression with alkaloid accumulation phenotypes was evident, including low putrescine methyltransferase expression for all species in the Suaveolentes section or clear correlation of nicotine demethylase with conversion rates of nicotine to nornicotine in majority of species. Multiple addnl. correlations between alkaloid accumulation and gene expression values were identified, which makes this study an important fundament toward future scientific exploration of the Nicotiana genus.
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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI