Electric Literature of 18531-94-7, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 18531-94-7, Name is (R)-[1,1′-Binaphthalene]-2,2′-diol, molecular formula is C20H14O2. In a Article£¬once mentioned of 18531-94-7
Synthesis of chiral 3,3?-disubstituted 1,1?-binaphthyl-2, 2?-disulfonic acids
A convenient synthesis of chiral 3,3?-disubstituted 1,1?-binaphthyl-2,2?-disulfonic acids (BINSA, 1) was developed. The key was directed ortho-lithiation of BINSA methyl ester 2 with n-BuLi and subsequent reaction with an electrophile. Electrophiles such as Br2, I2, Me3SiOTf, and i-PrOB(Pin) reacted smoothly with 3,3?-dilithiated BINSA methyl ester, and the corresponding 3,3?-dihalo-, 3,3?-bis(trimethylsilyl)-, and 3,3?-diboryl- BINSA derivatives were obtained in yields of 21-78%. This simple synthetic method is highly attractive since the ability to prepare 3,3?- disubstituted BINOLs in advance can be useful.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Electric Literature of 18531-94-7, you can also check out more blogs about18531-94-7
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI