Category: 100125-12-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.100125-12-0,3,8-Dibromo-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

General procedure: Activated Mg turnings (0.71 g, 29.21 mmol) in anhydrous thf (5 mL) and a catalytic amount of iodine were added to a flame-dried 100 mL three-necked flask and stirred vigorously at room temperature under argon. Then a solution of 2-bromo-5- methylthiophene (1.7 mL, 15.10 mmol) in anhydrous thf (5 mL) was slowly added dropwise to the reaction mixture. Once the vigorous reaction had started, the rest of the 2-bromo-5-methylthiophene solution was added dropwise to keep the mixture at reflux. The mixture was then heated at reflux for 30 min and added through a cannula into an ice-cooled solution of 3,8-dibromo-1,10- phenanthroline (2.01 g, 5.95 mmol) and [Ni(dppp)Cl2] (0.09 g, 0.17 mmol) in dry thf (50 mL). After stirring at room temperature for 2 h, the reaction mixture was heated at reflux for another 12 h, cooled to room temperature, quenched with saturated NH4Cl aqueous solution, and extracted thoroughly with chloroform (CHCl3) until no more products could be detected by TLC. The organic layer was washed with brine and purified by column chromatography (silica gel; CHCl3/petroleum ether, 1:1).

100125-12-0, The synthetic route of 100125-12-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhang, Bo; Cao, Kou-Sen; Xu, Ze-An; Yang, Zhe-Qin; Chen, Hao-Wen; Huang, Wei; Yin, Gui; You, Xiao-Zeng; European Journal of Inorganic Chemistry; 24; (2012); p. 3844 – 3851;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.100125-12-0,3,8-Dibromo-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

General procedure: A mixture of stoichiometric amounts of sodium tetrafluoroborate (0.110 g, 1.0 mmol) in 10 cm3 water and 3-bromo-phen (0.259 g, 1.0 mmol) in 40 cm3 ethanol was refluxed for 2 h. The mixture was cooled to room temperature and concentrated to nearly dry using a rotatory evaporator, and then the resulting precipitate 2 was filtered and washed by diethyl ether and dried in a vacuum. Yield: 0.28 g (75.9%).

100125-12-0, As the paragraph descriping shows that 100125-12-0 is playing an increasingly important role.

Reference£º
Article; Qian, Hui-Fen; Liu, Yuan; Tao, Tao; Gu, Ke-Hua; Yin, Gui; Huang, Wei; Inorganica Chimica Acta; vol. 405; (2013); p. 1 – 8;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

100125-12-0, 3,8-Dibromo-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: [Cu(CH3CN)4]ClO4 (32.6 mg, 0.100 mmol) was added to a dichloromethane (DCM) solution (about 10 mL) of BrphenBr (33.6 mg, 0.100 mmol) and BINAP (63.5 mg, 98%, 0.100 mmol) under a stream of dry argon using Schlenk techniques at room temperature. After stirring for 5 h at room temperature, n-hexane was carefully dropped over the DCM solution, and orange-yellow crystals were obtained a few days later in 52.5% yield (67.9 mg)., 100125-12-0

The synthetic route of 100125-12-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Feng, Xiao-Yan; Xin, Xue-Lian; Guo, Ya-Meng; Chen, Ling-Ling; Liang, Yu-Ying; Xu, Min; Li, Xiu-Ling; Polyhedron; vol. 101; (2015); p. 23 – 28;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI