Category: 105-83-9

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 105-83-9, molcular formula is C7H19N3, introducing its new discovery. Safety of N1-(3-Aminopropyl)-N1-methylpropane-1,3-diamine

The three dimers 3, 4, and 5 of mitomycin C (MC), a natural antibiotic and cancer chemotherapeutic agent, were synthesized in which two MC molecules were linked with -(CH2)4-, -(CH2)12-, and -(CH2)3N(CH3)(CH2)3- tethers, respectively. The dimeric mitomycins were designed to react as polyfunctional DNA alkylators, generating novel types of DNA damage. To test this design, their in vitro DNA alkylating and interstrand cross-linking (ICL) activities were studied in direct comparison with MC, which is itself an ICL agent. Evidence is presented that 3-5 multifunctionally alkylate and cross-link extracellular DNA and form DNA ICLs more efficiently than MC. Reductive activation, required for these activities, is catalyzed by the same reductases and chemical reductants that activate MC. Dimer 5, but not MC, cross-linked DNA under activation by low pH also. Sequence specificities of cross-linking of a 162-bp DNA fragment (tyrT DNA) by MC, 3, and 5 were determined using DPAGE. The dimers and MC cross-linked DNA with the same apparent CpG sequence specificity, but 5 exhibited much greater cross-linking efficacy than MC. Greatly enhanced regioselectivity of cross-linking to G·C rich regions by 5 relative to MC was observed, for which a mechanism unique to dimeric MCs is proposed. Covalent dG adducts of 5 with DNA were isolated and characterized by their UV and mass spectra. Tri- and tetrafunctional DNA adducts of 5 were detected. Although the dimers were generally less cytotoxic than MC, dimer 5 was highly and uniformly cytotoxic to all 60 human tumor cell cultures of the NCI screen. Its cytotoxicity to EMT6 tumor cells was enhanced under hypoxic conditions. These findings together verify the expected features of the MC dimers and warrant further study of the biological effects of dimer 5.

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Reference of 105-83-9, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.105-83-9, Name is N1-(3-Aminopropyl)-N1-methylpropane-1,3-diamine, molecular formula is C7H19N3. In a article，once mentioned of 105-83-9

A series of bis(11-oxo-11H-indeno[1,2-b]quinoline-6-carboxamides) linked through the 6-carboxamides were prepared by coupling the requisite acid imidazolides with various diamines. Compounds with mono-cationic linker chains were more potent cytotoxins than the corresponding monomer in a panel of rodent and human cell lines, while those with the dicationic linker chains (CH2)2NR(CH2)2NR(CH2)2 and (CH2)2NR(CH2)3NR(CH2)2 showed extraordinarily high potencies (for example, IC50s of 0.18-1.4 nM against human Jurkat leukemia; up to 1000-fold more potent than the parent monomer). As seen previously in the monomeric series, small, lipophilic 4-substituents significantly increased potency in cell culture. The dimeric compounds were all slightly to significantly more potent in the mutant JL(A) and JL(D) cell lines that under-express topo II, suggesting that this enzyme is not their primary target. An 11-imino-linked dimer was much less active, and an asymmetric indeno[1,2-b]quinoline-6-carboxamide/naphthalimide dimer was less active than the comparable symmetric bis(indeno[1,2-b]quinoline-6- carboxamide). Selected analogues were active against sub-cutaneously implanted colon 38 tumors in mice, giving growth delays comparable to that of the clinical topo I inhibitor irinotecan at up to 10-fold lower doses. These compounds form an interesting new class of putative topo I inhibitors. (C) 2000 Elsevier Science Ltd.

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Synthetic Route of 105-83-9, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 105-83-9, Name is N1-(3-Aminopropyl)-N1-methylpropane-1,3-diamine,introducing its new discovery.

Chiral metal complex with self-complementary multiple-faced H-bonding recognition unit is a good candidate to produce conglomerate. This article describes chiral 1D and 2D extended assembly structures derived from intermolecular homochiral interaction of self-complementary metal complex.

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Reference of 105-83-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.105-83-9, Name is N1-(3-Aminopropyl)-N1-methylpropane-1,3-diamine, molecular formula is C7H19N3. In a Article，once mentioned of 105-83-9

In the series of 1-pyrenylmethylamines studied in this work the relationships among structure, interaction with DNA, and murine antitumor activity were examined.Binding studies show that all of these 1-pyrenylmethylamine derivatives bind to some extent to DNA by intercalation.The presence of additional basic amine groups in the side chain enhances DNA binding due to electrostatic interactions.Those compounds containing only a single basic benzylic amine bind similarly to DNA.Only the presence of bulky side chains appears to decrease the DNA interactions in the compounds examined.Although antitumor activity is seen for (1-pyrenylmethyl)amino alcohols, useful antitumor activity in the series is limited to those congeners bearing the 2-amino-1,3-propanediol-type side chain.These derivatives bind moderately to DNA.DNA binding is a necessary but not sufficient criterion for antitumor activity in the series.In addition, the strength of DNA binding does not correlate with the antitumor activity in the group of active compounds.Three related 2-<(arylmethyl)amino>-1,3-propanediol derivatives (AMAPs) are currently in clinical trials as potential antitumor agents.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 105-83-9 is helpful to your research. Reference of 105-83-9

Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 105-83-9, name is N1-(3-Aminopropyl)-N1-methylpropane-1,3-diamine, introducing its new discovery. Quality Control of: N1-(3-Aminopropyl)-N1-methylpropane-1,3-diamine

The good results obtained with pyrimido[5,6,1-de]acridines 7 and with pyrazolo[3,4,5-kl]-acridinecarboxamides 8 prompted us to the synthesis of two new series of bis acridine derivatives: the bis(pyrimidoacridines) 5 and the bis(pyrazoloacridinecarboxamides) 6. Compounds 5 can be regarded also as cyclized derivatives of bis(acridine-4-carboxamides) 3 and compounds 6 as cyclized derivatives of bis(acridine-4-carboxamides) 4. The noncovalent DNA-binding properties of these compounds have been examined using fluorometric techniques. The results indicate that (i) the target compounds are excellent DNA ligands; (ii) the bis derivatives 5 and 6 are more DNA-affinic than corresponding monomers 7 and 8; (iii) the new bis 5 and 6 result always less efficient in binding than related bis(acridine-4-carboxamides) 3 and 4; and (iv) in both series 5 and 6 a clear, remarkable in some cases, preference for binding to AT rich duplexes can be noted. In vitro cytotoxic potency of these derivatives toward the human colon adenocarcinoma cell line (HT29) is described and compared to that of reference drugs. Structure – activity relationships are discussed. We could identify six very potent cytotoxic compounds for further in vitro studies: a cytotoxic screening against six human cancer cell lines and the National Cancer Institute (NCI) screening on 60 human tumor cell lines. Finally, compound 6a was selected for evaluation in a NCI in vivo hollow fiber assay.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 105-83-9 is helpful to your research. Quality Control of: N1-(3-Aminopropyl)-N1-methylpropane-1,3-diamine

Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Reference of 105-83-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 105-83-9, Name is N1-(3-Aminopropyl)-N1-methylpropane-1,3-diamine, molecular formula is C7H19N3. In a Article，once mentioned of 105-83-9

A series of mono-, bis- and tetra-acridine ligands were prepered and their effects on the higher order structure of DNA were studied by dynamic fluorescence microscopy.The single-crystal sructure of the bis0acridine derivative N-<2-(dimethylamino) ethyl>-4-<2-(9-acridinylamino)benzamido>-2-(9-acridinyamino)benzamide trihydrochloride (4) was determined, and shows that the molecule is sufficiently flexible to fold into an intramolecular stacking interaction in the crystal, supporting earlier hydrodynamic evidence that this compound can bis-intercalate into DNA forming a single base pair (bp) sandwich complex.The corresponding tetra-acridineanalogue 1,11-bis<4-<2-(9-acridinylamino)benzamido>-2-(9-acridinylaminophenyl>-1,11-dioxo-6-methyl-2,6,10-triazaundecane pentahydrochloride (6) was synthesized, and dynamic fluorescence microscopy was used to study the effects of 4 and 6 on the higher order structure of large T4 DNA molecules (166 kbp), by measuring the average long-axis lenght (persistence lenght, l) of the complexes.The mono-intercalating ligand acridine orange (5) increases l, whereas the bisintercalating diacridine 4 has no apparent effect and the putative multi-intercalating teraacridine derivative 6 decreases l by compacting the higher order DNA structure.These results demonstrate the usefulness of the technique for directly observing ligand-DNA complexes, and show that ligands with suitable positioned multiple binding sites can influence the higher order structure of DNA (and thus possibly gene expression).

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Application In Synthesis of N1-(3-Aminopropyl)-N1-methylpropane-1,3-diamine, Which mentioned a new discovery about 105-83-9

Six new nickel(II) binuclear oxalato-bridging compounds were obtained and crystal structures were solved at room temperature. Factors influencing the nitrite coordination modes are discussed. [mer-Ni2(3,3?-diamino-N-methyldipropylamine) 2(OH2)2(mu-OX)]Cl2·3H 2O (I), Ni2C16Cl2H48N6O 9 is a mu-oxalato bridged dimer with a Medpt ligands in the mer conformation, a nitro(N) ligand trans to the N-methyl group and a water ligand trans to an oxalato oxygen. Green [fac-Ni2(3,3?-diamino-N-methyldipropylamine) 2(ONO)2(mu-OX)] (II), Ni2C16H38N8O8 is also a mu-oxalato bridged dimer with a fac-Medpt, making this substance unique since it is the only fac-dpt compound ever made. The nitro(O) ligand is trans to the N-methyl group. Violet [mer-Ni2(3,3?-diamino-N-methyldipropylamine) 2(NO2)2(mu-OX)]·2H2O (III), Ni2C16H42N8O10 is interesting as this compound came from the same reaction pot as II. The two are readily separated by hand since their colors differ drastically. It is also a mu-oxalato bridged dimer with mer-Medpt but the nitro ligand is (O) bound and trans to an oxalato oxygen. [mer-Ni2(N-(3-aminopropyl)-1,3-propanediamine)2(OH 2)2(mu-OX)]Cl2 (IV), Ni2C14Cl2H38N6O 6 is also a mu-oxalato bridged dimer with an unmethylated dpt ligand in mer conformation. The sixth position of the coordination sphere is a water located trans to an oxalato oxygen. [mer-Ni2(N-(3-aminopropyl)-1,3-propanediamine)2(OH 2)2(mu-OX)]Cl(NO2) (V), Ni2C14ClH38N7O8. The amine ligand of both nickels are mer, an oxalato bridge links the two metal centers and a water occupies a site trans to an oxalato oxygen. It is surprising to find a nitro ligand as a counter ion while a water occupies a coordination site. Normally, one would expect displacement of the aquo ligand by NO2-. [mer-Ni2(N-(2-aminoethyl)-1,3-propanediamine)2(OH 2)2(mu-OX)](ClO4)2 (VI), Ni2C12Cl2H34N6O 14. The mer-aep and the mu-oxalato ligands fill five positions of the coordination sphere of this dimer. The other positions are taken up by water molecules located trans to an oxalato oxygen. The structures of all six compounds were determined and the temperature dependence of their magnetic susceptibility were also established.

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Formula: C7H19N3, Which mentioned a new discovery about 105-83-9

This invention is concerned with novel polycyclic compounds of formula [I], 1wherein ring A, ring B, R1, R2, R3, R4, R5, R6, X, Y, R1, R2?, R3?, R4?, R5?, R6?, ring A?, ring B? and X? are as defined hereinabove as well as pharmaceutically acceptable salts thereof. The compounds have anti-tumor activity and are useful for the treatment of cell proliferative disorders.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, category: catalyst-ligand, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 105-83-9

Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chemistry is traditionally divided into organic and inorganic chemistry. category: catalyst-ligand. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 105-83-9

CRISPR/Cas is a revolutionary gene editing technology with wide-ranging utility. The safe, non-viral delivery of CRISPR/Cas components would greatly improve future therapeutic utility. We report the synthesis and development of zwitterionic amino lipids (ZALs) that are uniquely able to (co)deliver long RNAs including Cas9 mRNA and sgRNAs. ZAL nanoparticle (ZNP) delivery of low sgRNA doses (15 nm) reduces protein expression by >90 % in cells. In contrast to transient therapies (such as RNAi), we show that ZNP delivery of sgRNA enables permanent DNA editing with an indefinitely sustained 95 % decrease in protein expression. ZNP delivery of mRNA results in high protein expression at low doses in vitro (<600 pM) and in vivo (1 mg kg?1). Intravenous co-delivery of Cas9 mRNA and sgLoxP induced expression of floxed tdTomato in the liver, kidneys, and lungs of engineered mice. ZNPs provide a chemical guide for rational design of long RNA carriers, and represent a promising step towards improving the safety and utility of gene editing. Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: catalyst-ligand, you can also check out more blogs about105-83-9

Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Synthetic Route of 105-83-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.105-83-9, Name is N1-(3-Aminopropyl)-N1-methylpropane-1,3-diamine, molecular formula is C7H19N3. In a Patent，once mentioned of 105-83-9

The present invention provides compounds, compositions thereof, and methods of using the same.

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI