Category: 10534-59-5

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Step-2 product (100 mg, 0.268 mmol) in a mixture of dichloromethane and N,N’-dimethylformamide (250 mu?^ each) was added 10% palladium on carbon (25 mg) and the resulting mixture was stirred under hydrogen atmosphere for 1 hour at 25C to 35C. The catalyst was filtered through micron filter and the filtrate was concentrated under vacuum below 40C to provide a residue. The residue was dissolved in N,N-dimethylformamide (500 mu?^) and N,N-dimethylformamide sulfurtrioxide complex (50 mg, 0.321 mmol) was added in one lot at 0C temperature. The mixture was stirred for 1 hour. The aqueous tetrabutyl ammonium acetate solution (97 mg, 0.321 mmol dissolved in 350 mu?^ water) was then added to it. The reaction mixture was allowed to warm to 25C to 35C. and stirred further for 1 hour. The volatiles were removed under vacuum to provide a residue and residue was triturated with xylene (10 ml) to remove traces of N,N- dimethylformamide. Residue was partitioned between water (10 ml) and dichloromethane (10 ml). Aqueous layer was re-extracted with dichloromethane (10 ml). Combined organic extracts were washed with water (10 ml) and brine (10 ml). Organic layer was dried over sodium sulfate and concentrated under vacuum to obtain yellow oil as the Step-3 product, in 100 mg quantity (yield 62%). Analysis: MS: 361.2 (M-H) of free sulfonic acid; M.W: 603: M.F:

10534-59-5, The synthetic route of 10534-59-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; WOCKHARDT LIMITED; BHAGWAT, Sachin; DESHPANDE, Prasad Keshav; BHAWASAR, Satish; PATIL, Vijaykumar Jagdishwar; TADIPARTHI, Ravikumar; PAWAR, Shivaji Sampatrao; JADHAV, Sunil Bhaginath; DABHADE, Sanjay Kisan; DESHMUKH, Vikas Vitthalrao; DHOND, Bharat; BIRAJDAR, Satish; SHAIKH, Mohammad Usman; DEKHANE, Deepak; PATEL, Piyush Ambalal; WO2013/30735; (2013); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10534-59-5,Tetrabutylammonium acetate,as a common compound, the synthetic route is as follows.

General procedure: 1H-NMR spectra were recorded on a DRX 400 (9.4 T, 400.13 MHz) spectrometer (Bruker Espanola S.A., Madrid, Spain) at 300 K. The [Host] values in the range of 1.02 to 1.85 ¡Á 10-3 correspond to a weighted quantity of host in 2 mL of CDCl3 (S33657, deuterium content >99.8%, water content <0.01%, containing silver wire as stabilizer, Merck S.L., Mollet del Valles-Barcelona, Spain). A given quantity of the guest (about 2 ¡Á 10-2 M) was weighed in a 1 mL volumetric flask and host solution was added to reach the graduation mark; in this way we know that the host concentration remains constant. Host and guest were weighted in a AE260-Delta Range scale (error ¡À 0.00005 g, Mettler Toledo, L' Hospitalet de Llobregat-Barcelona, Spain) and eVol XR hand-held automated analytical syringes (500 muL, 50 muL) from SGE Analytical Science (Trajan Scientific Europe Ltd, Crownhill, Milton Keynes, United Kingdom) previously calibrated for CDCl3, were used to perform additions. 1H-NMR titrations were used to quantify Ka values (see Figure 5 for two representative plots)., 10534-59-5

The synthetic route of 10534-59-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Garcia, M. Angeles; Farrn, M. Angeles; Mara, Dolores Santa; Claramunt, Rosa M.; Torralba, M. Carmen; Torres, M. Rosario; Jaime, Carlors; Elguero, Jos; Molecules; vol. 20; 6; (2015); p. 9862 – 9878;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10534-59-5,Tetrabutylammonium acetate,as a common compound, the synthetic route is as follows.

10534-59-5, General procedure: A solution of H6buea (200 mg, 0.45 mmol) dissolved in 4 mL of anhydrous DMA was treated with solid KH (55 mg, 1.36 mmol) and stirred until gas evolution ceased. Fe(OAc)2 (79 mg, 0.45 mmol) was added to the pale yellow solution, and stirring was continued for 30 min. The resulting amber filtrate was treated with [Bu4N][OAc] (140 mg, 0.45 mmol) and stirred for 2 h, resulting in the precipitation of a white solid (305 mg) that was filtered, washed twice with Et2O, and dried under vacuum. The white solid was stirred in CH3CN for 1 h and filtered to remove KOAc (105 mg, 96%). The light yellow filtrate was concentrated to half its original volume and the slow addition of Et2O resulted in the formation of a white solid, which was then filtered, washed with Et2O, and dried under vacuum to afford 150 mg (47%) of the desired salt. [Bu4N]2[Fe(II)H22iPr]2 was prepared following a similar procedure to that of [Bu4N]2[Fe(II)H3buea]2 with H52iPr (150 mg, 0.37 mmol), KH (45 mg, 1.12 mmol), Fe(OAc)2 (66 mg, 0.37 mmol), and [Bu4N][OAc] (113 mg, 0.37 mmol). The amount of KOAc obtained was 105 mg (96% for 3 equiv) and 100 mg (42%) of [Bu4N]2[FeIIH22iPr] was isolated. FTIR (Nujol, cm-1) nu(NH) 3332, nu(CO) 1661, 1590, 1561, 1520. Repeated attempts to obtain a satisfactory elemental analysis were unsuccessful.

The synthetic route of 10534-59-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Lacy, David C.; Mukherjee, Jhumpa; Lucas, Robie L.; Day, Victor W.; Borovik; Polyhedron; vol. 52; (2013); p. 261 – 267;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The solution containing the sulfate (X) was re-cooled to 0 C. and a solution of Tetra butyl ammonium acetate (9 gm, 0.0301 mol dissolved in 30 ml water) was added to it. The reaction mixture was allowed to warm to 25 C. and stirred for 1 hour. The volatiles were removed under reduced pressure and residue was co-evaporated with 2¡Á50 ml Xylene to remove traces of N,N?-Dimethyl formamide. The residue was partitioned between a 1:1 mixture of water and dichloromethane (120 ml). The aqueous layer was re-extracted with dichloromethane (30 ml). The combined organic extracts were washed with water (2¡Á30 ml), brine (30 ml). And dried over Na2SO4 and the solvent evaporated under reduced pressure to obtain the crude TBA sulfate (5.2 gm). Crude compound was triturated with hexane (2¡Á30 ml) & dried on rotavapor under 4 mmHg pressure to obtain the TBA salt (XI), 5.0 g, yield-44%. [0109] Mass: 246 ((M-H)) of sulfate M.W: 488, M.F: C23H44N4O5S., 10534-59-5

10534-59-5 Tetrabutylammonium acetate 82707, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Patil, Vijaykumar Jagdishwar; Tadiparthi, Ravikumar; Birajdar, Satish; Bhagwat, Sachin; US2014/88070; (2014); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3: Preparation of tetrabutylammonium salt of 4-{3-[(25,5/f)-6-(sulfooxy)-7-oxo-l,6-diaza- bicyclo[3.2.1]octane-2-carbonyl]-ureido}-piperidine-l-carboxylic acid tert-butyl ester: To a stirred solution of 4-{ 3-[(2S,5R)-(6-hydroxy-7-oxo-l,6-diaza-bicyclo[3.2.1]octane-2-carbonyl)-ureido] }- piperidine-l-carboxylic acid tert-butyl ester (0.41 g, 0.0009 mol) in dimethylformamide (4.1 ml), at 10C, was added dimethylformamide sulfur trioxide complex (0.183 g, 0.0019 mol) in one portion. The reaction mass was stirred at the same temperature for about 30 minutes and then allowed to warm to room temperature. After 1 hour, to the resulting reaction mixture was added slowly a solution of tetrabutylammonium acetate (0.359 g, 0.0019 mol) in dichloromethane (2 ml) under stirring. After 1 hour, the solvent from the reaction mixture was evaporated under reduced pressure to yield an oily residue. The oily mass was co-evaporated with xylene (2x10ml) to obtain a thick mass. This mass was partitioned between dichloromethane (10 ml) and water (10 ml). The combined organic extracts were washed with water (3xl0ml) and dried over anhydrous sodium sulphate.The solvent was evaporated under reduced pressure and the resulting oily mass was triturated with ether (3×10 ml), each time the ether layer was decanted and finally the residue was concentrated under reduced pressure to obtain 0.260 g of the titled product as white foam in 35% yield.Analysis:Mass: 490.4 (M-l) as free acid; for Molecular Weight: 732.9, Molecular Formula: C34H64N6O9S .

10534-59-5, As the paragraph descriping shows that 10534-59-5 is playing an increasingly important role.

Reference£º
Patent; WOCKHARDT LIMITED; TADIPARTHI, Ravikumar; PATIL, Vijaykumar Jagdishwar; KALE, Amol; SHAIKH, Mohammad Usman; PATEL, Mahesh Vithalbhai; (65 pag.)WO2016/116788; (2016); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of (25,5 ?)-Lambda^- [(5-ieri-butoxycarbonylamino-lH-tetrazol-l-yl)acetyl]-7-oxo-6-oxy-l,6-diazabicyclo[3.2.1] octane-2-carbohydrazide (4.65 g, 1.5 mmol, product from Step 6) in dimethylformamide (30 ml) was added dimethylformamide sulfur trioxide complex (2.76 g, 1.8 mmol) in one portion at 0C under argon atmosphere. The reaction mass was stirred at the same temperature for 30 minutes and allowed to attain ambient temperature. The reaction was monitored by thin layer chromatography using mixture of chloroform and methanol (9: 1) as solvent. After complete consumption of starting material tetrabutyl ammonium acetate (5.42 g, 1.8 mmol) dissolved in 20 ml of water was added to it at 25-30 C under stirring. The reaction was monitored by thin layer chromatography using mixture of chloroform and methanol (9: 1) as solvent. After complete consumption of starting material the volatiles were removed under reduced pressure. The residue was partitioned between dichloromethane (200 ml) and water (100 ml). The water layer was separated and organic layer washed with water (100 ml). The organic extract was dried over anhydrous sodium sulfate and concentrated under reduced pressure to provide 7.8 g of tetrabutyl ammonium salt of (2S,5R)-6- (sulfooxy)-7-oxo-N’-(lH-tetrazol- l-ylacetyl)- l,6-diaza bicycle [3.2.1]octane-2-carbohydrazide in 82% yield. Analysis: 9.3 (M- l) for free acid; for Molecular weight: 631 and Molecular formula: CioHi3N807S. (400MHz, DMSO-d6): S 7.93 (s, 1H), 5.33 (s, 2H), 3.97 (bs, 1H), 3.83(m, 1H), 3.14-3.10 (m, 9H), 2.87(m, 1H), 2.11- 1.5 (m, 4H), 1.54 (m, 8H), 1.33- 1.24 (m, 8H), 0.93-0.89 (m, 12H)., 10534-59-5

The synthetic route of 10534-59-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; WOCKHARDT LIMITED; TADIPARTHI, Ravikumar; PATIL, Vijaykumar Jagdishwar; DEKHANE, Deepak; SHAIKH, Mohammad Usman; BIRAJDAR, Satish; DOND, Bharat; PATEL, Mahesh Vithalbhai; (100 pag.)WO2017/81615; (2017); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Preparation of four different solutions of tetradecavanadates, VxOyALz (A = Cl- or CH3CO2-, L = (C2H5)4N+ or (C4H9)4N+), was carried out according to a modified literature procedure [31]. All chemicals were purchased from Sigma-Aldrich and used as received. Briefly, 1.5 mmol of vanadyl acetylacetonate [VO(acac)2] and 0.6 mmol of either tetraethylammonium chloride [(C2H5)4NCl], tetrabutylammonium chloride [(C4H9)4NCl], tetraethylammonium acetate [(C2H5)4N(CH3CO2)] or tetrabutylammonium acetate [(C4H9)4N(CH3CO2)] were dissolved in 50 mL of acetonitrile. 0.8 mmol of triethyl amine was then added to the initial mixtures while stirring constantly at room temperature. Following 6 h of reaction, an Oakton 10 series pH meter (calibrated using buffers of pH 4, 7 and 10 at room temperature) was used to determine the pH of the resulting brown-colored solutions. The product mixtures were de-solvated under reduced pressure using a VWR1400E vacuum oven. Recrystallization was carried out in approximately 3 mL of N,N-dimethylformamide (N,N-DMF) by heating the solution to the boiling temperature (153 C) for 10 min. Any remaining N,N-DMF was then evaporated in vacuum to obtain pure dry crystals of polyoxovanadates. A small quantity of crystals was dissolved in acetonitrile to prepare concentrated stock solutions. These stock solutions were diluted further by factors of ten or one hundred in acetonitrile prior to analysis by ESI-MS.

10534-59-5, The synthetic route of 10534-59-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Johnson, Grant E.; Al Hasan, Naila M.; Laskin, Julia; International Journal of Mass Spectrometry; vol. 354-355; (2013); p. 333 – 341;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of a tetrabutylammonium salt of (2S,5R)-N-{[1-tert-butoxycarbonyl (2R, 4S)-4-(morpholin-4-yl)pyrrolidin-2-ylj methoxy } -6-hydroxy-7-oxo- 1,6- diazabicyclo[3.2.ljoctane-2-carboxamide (1.5 g, 0.0032 mol) in dimethylformamide (15 ml) was added sulfur trioxide: dimethylformamide complex (1.0 g, 0.0064 mol) under stirring at temperature of about 0 C. The reaction mixture was stirred at 0 C for 10 minutes and then allowed to warm to 25C. After 1 hr of stirring a solution of tetra butyl ammonium acetate (2.89 g, 0.0096 mol) in water (8 ml) was added to the reaction mixture under continuous stirring. After completion of 1 hr stirring the solvent from the reaction mixture was evaporated under reduced pressure to obtain an oily residue. The residue obtained was then purified by silica gel(60-120 mesh size) column chromatography using 6% Methanol: DCM mixture as an eluant to get required compound. The solvent of the combined fractions were evaporated to provide 1.2 g of the titled compound as white solid, 47% yield. Analysis:Mass: 548.4 (M-1) as free acid; for Molecular weight: 791.07 and Molecular formula:C37H70N60 ftS?H NMR (CDC13, 400 MHz): 5 10.42 (brs, 1H), 4.38-4.28 (m, 1H), 3.98-3.92 (m, 1H), 3.86- 3.68 (m, 5H), 3.62-3.52 (m, 1H), 3.42-3.20 (m, 1OH), 2.98-2.84 (m, 2H), 2.58-2.32 (m, 5H), 2.24-2.14 (m, 1H), 1.96-1.84 (m, 2H), 1.84-1.62 (m, 12H), 1.56-1.42 (m, 17H), 1.06-0.97 (m, 12H).

10534-59-5, 10534-59-5 Tetrabutylammonium acetate 82707, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; WOCKHARDT LIMITED; PATIL, Vijaykumar Jagdishwar; SHENGULE, Sudhir; PAWAR, Mangesh; BHUNIYA, Rajib; MUNSHI, Zaki Ahmed Burhanuddin; JOSHI, Prashant Ratnakar; TAKALKAR, Swapna Shripad; PATEL, Mahesh Vithalbhai; (64 pag.)WO2017/98425; (2017); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of a tetrabutylammonium salt of (2S,5R)-N-{[1-tert-butoxycarbonyl (2R, 4S)-4-(morpholin-4-yl)pyrrolidin-2-ylj methoxy } -6-hydroxy-7-oxo- 1,6- diazabicyclo[3.2.ljoctane-2-carboxamide (1.5 g, 0.0032 mol) in dimethylformamide (15 ml) was added sulfur trioxide: dimethylformamide complex (1.0 g, 0.0064 mol) under stirring at temperature of about 0 C. The reaction mixture was stirred at 0 C for 10 minutes and then allowed to warm to 25C. After 1 hr of stirring a solution of tetra butyl ammonium acetate (2.89 g, 0.0096 mol) in water (8 ml) was added to the reaction mixture under continuous stirring. After completion of 1 hr stirring the solvent from the reaction mixture was evaporated under reduced pressure to obtain an oily residue. The residue obtained was then purified by silica gel(60-120 mesh size) column chromatography using 6% Methanol: DCM mixture as an eluant to get required compound. The solvent of the combined fractions were evaporated to provide 1.2 g of the titled compound as white solid, 47% yield. Analysis:Mass: 548.4 (M-1) as free acid; for Molecular weight: 791.07 and Molecular formula:C37H70N60 ftS?H NMR (CDC13, 400 MHz): 5 10.42 (brs, 1H), 4.38-4.28 (m, 1H), 3.98-3.92 (m, 1H), 3.86- 3.68 (m, 5H), 3.62-3.52 (m, 1H), 3.42-3.20 (m, 1OH), 2.98-2.84 (m, 2H), 2.58-2.32 (m, 5H), 2.24-2.14 (m, 1H), 1.96-1.84 (m, 2H), 1.84-1.62 (m, 12H), 1.56-1.42 (m, 17H), 1.06-0.97 (m, 12H).

10534-59-5, 10534-59-5 Tetrabutylammonium acetate 82707, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Patent; WOCKHARDT LIMITED; PATIL, Vijaykumar Jagdishwar; SHENGULE, Sudhir; PAWAR, Mangesh; BHUNIYA, Rajib; MUNSHI, Zaki Ahmed Burhanuddin; JOSHI, Prashant Ratnakar; TAKALKAR, Swapna Shripad; PATEL, Mahesh Vithalbhai; (64 pag.)WO2017/98425; (2017); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI