Category: 128143-89-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.128143-89-5,4′-Chloro-2,2′:6′,2”-terpyridine,as a common compound, the synthetic route is as follows.

Compound M (18.00 g, 34.25 mmol) and compound N (12.23 g, 34.25 mmol) were completely dissolved in 300 ml of tetrahydrofuran in a 500 ml round-bottomed flask under nitrogen atmosphere, and 2M aqueous potassium carbonate solution (150 ml)Tetrakis- (triphenylphosphine) palladium (1.18 g, 1.02 mmol) was added thereto, followed by heating and stirring at 75C for 3 hours. The temperature was lowered to room temperature (23 ¡À 5 C), the water layer was removed, dried over anhydrous magnesium sulfate, concentrated under reduced pressure, and recrystallized from 120 ml of ethyl acetate to obtain Compound 10 (16.9 g, 74%

128143-89-5, 128143-89-5 4′-Chloro-2,2′:6′,2”-terpyridine 667748, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; LG CHEMICAL LTD; LG Chem, Ltd.; YANG JUNG HOON; Yang Jeong-hun; LEE DONG HOON; Lee Dong-hun; HUH JUNG OH; Huh Jeong-o; JANG BOON JAE; Jang Bun-jae; HEO DONG UK; Huh Dong-uk; HAN MI YEON; Han Mi-yeon; YUN HEE KYUNG; Yoon Hui-gyeong; (47 pag.)KR2019/9704; (2019); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

128143-89-5, 4′-Chloro-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4′-(2-Aminoethanesulfanyl)-2,2′:6′,2”-terpyridine (2a) was prepared from reaction of the 4′-chloroterpyridine 8a (at 50 C for 3 h) or the 4′-iodoterpyridine 7a (at 70 C for 2 h) with 2-aminoethanethiol hydrochloride and sodium hydride in DMF. The reactions gave the target compound 2a in 75% and 86% yields, respectively.The 1H and 13C NMR spectral data of 2a were consistentwith literature data., 128143-89-5

The synthetic route of 128143-89-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Lin, Chih-Pei; Florio, Pas; Campi, Eva M.; Zhang, Chunfang; Fredericks, Dale P.; Saito, Kei; Jackson, W. Roy; Hearn, Milton T.W.; Tetrahedron; vol. 70; 45; (2014); p. 8520 – 8531;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

128143-89-5, 4′-Chloro-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Powdered KOH (280mg, 5mmol) was added to 10mL dry dimethyl sulfoxide (DMSO) and 8-Amino-1-octanol (152.5mg, 1.05mmol) was then added and stirred at 60C for 1h. Then, 4?-Chloro-2,2′:6?,2?-terpyridine (268mg, 1.0mmol) was added, and the resulting mixture was stirred at 60C for 48h. After cooled to room temperature, the reaction mixture was poured into deionized water (200mL) to yield precipitation, which was collected by filtration. The yellow solid was washed with deionized water, and then dried under vacuum overnight to afford 290mg of the desired product in 77% yield [30]. 1H NMR (400MHz, CDCl3) delta 8.74-8.66 (m, 2H), 8.62 (d, J=8.0Hz, 2H), 8.02 (d, J=9.1Hz, 2H), 7.85 (td, J=7.8, 1.8Hz, 2H), 7.33 (ddd, J=7.5, 4.8, 1.1Hz, 2H), 4.22 (t, J=6.4Hz, 2H), 2.69 (t, J=7.0Hz, 2H), 1.90-1.81 (m, 2H), 1.56-1.28 (m, 10H). HRMS [M+ H]+ calcd for C23H29N4O+ 377.2341; found: 377.2340. Anal Cald for C23H28N4O: C, 73.37; H, 7.50; N, 14.88; Found: C, 73.32; H, 7.85; N, 14.75., 128143-89-5

The synthetic route of 128143-89-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hou, Zhaohui; Li, Peng; Wang, Huan-Yu; Li, Zhiqiang; Li, Huanrong; Dyes and Pigments; vol. 147; (2017); p. 429 – 435;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

128143-89-5, 4′-Chloro-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,128143-89-5

was added to a stirred suspensionof KOH (1.05 g, 18.7 mmol) in anhydrous DMSO(20 mL) at 60 C. After 60 min, 40-chloro-2,20:60,200-terpyridine (1.00 g, 3.7 mmol) was added to the mixture,which was maintained with stirring for 4 h at 70 C. Distilledwater (600 mL) was then added to the reaction mixture,and the product was extracted with CH2Cl2(3 ¡Á 200 mL). Residual water in the CH2Cl2 was removedusing Na2SO4, and the CH2Cl2 was removed using a rotaryevaporator. The desired product was recrystallized fromethyl acetate to give 0.72 g (72%) of 4. 1H NMR(300 MHz, CDCl3-d) 8.7 (d, 2H, J = 4.7 Hz), 8.6 (d, 2H,J = 7.4 Hz), 8.0 (m, 4H), 7.5 (m, 2H), 4.0 (m, 2H), 3.2(dd, 1H, J = 6.3 Hz and J = 12.5 Hz) 1.7 (s, 2H), 1.1 (d,3H, J = 6.4 Hz). 13C NMR (125 MHz, CDCl3-d) 160.2,156.5, 154.2, 148.9, 123.7, 120.8, 105.2, 70.1, 48.1, 21.4.ESI-MS (m/z) calcd. For C18H18N4O: 306.2; 307.307[M + H]+. Elemental analysis: calculated for C18H18N4O:C 70.6, H 5.9, N 18.3. Found: C 70.2, H 5.5, N 18.1.

128143-89-5 4′-Chloro-2,2′:6′,2”-terpyridine 667748, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Kim, Ka Young; Kim, Jaehyeong; Park, Hyesong; Choi, Yeonweon; Kwon, Ki-Young; Jung, Jong Hwa; Bulletin of the Korean Chemical Society; vol. 39; 8; (2018); p. 988 – 994;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

128143-89-5, 4′-Chloro-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of 6-(2,2′:6′,2″-Terpyridine-4′-yloxy)-hexylamine To a suspension of KOH (2.70 g, 48 mmol) in anhydrous DMSO (50 mL) was added 6-Amino-1-hexanol (1.17 g, 10 mmol). The suspension was warmed up to 60 C. and stirred for additional 30 min, followed by addition of 4′-chloro-2,2′:6′,2″-terpyridine (2.68 g, 10 mmol). The reaction mixture was kept stirring for 2 d at the same temperature. The solution was then allowed to cool down to R.T., poured into deionized water (500 mL), stirred and allowed to precipitate overnight. The product was filtered off and dried up under high vacuum to give 2 as a pale yellow solid (2.90 g, 83.3%). 1H NMR (400 MHz, CDCl3): delta 1.47-1.86 (m, 8H), 2.74 (t, J=6.5 Hz, 2H, NCH2), 4.22 (t, J=6.5 Hz, 2H, OCH2), 7.34 (dd, J=2.0 Hz, 5.0 Hz, 2H, H5,5″(terpy)), 7.84 (td, J=2.0 Hz, 7.5 Hz, 2H, H4,4″(terpy)), 8.03 (s, 2H, H3′,5′(terpy), 8.67 (d, J=8.5 Hz, 2H, H3,3″terpy)), 8.70 (d, J=5.0 Hz, 2H, H6,6″(terpy)). GC-MS: m/z 348 (100%) (M+).

128143-89-5, 128143-89-5 4′-Chloro-2,2′:6′,2”-terpyridine 667748, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Massachusetts Institute of Technology; CHEN, Pangkuan; HOLTEN-ANDERSEN, Niels; (58 pag.)US2016/152638; (2016); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

128143-89-5, 4′-Chloro-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The syntheses of ligands were carried out by literature procedures [48-50]. To a suspensionof KOH in dry DMSO at 50 C, ethylene glycol and its respective polymer (n = 2, 3, or 4)in excess were added. After stirring for 30 min, 4?-chloro-2,2? : 6?,2??-terpyridine was addedand the reaction mixture was stirred for 20 h at this temperature. Upon cooling to roomtemperature, the reacting mixture was treated with deionised water and filtered. The crudeproduct was extracted from the filtrate in dichloromethane (3 ¡Á 30 mL), dried overanhydrous magnesium sulfate, and then the solvent was removed., 128143-89-5

As the paragraph descriping shows that 128143-89-5 is playing an increasingly important role.

Reference£º
Article; Shaira; Jaganyi; Journal of Coordination Chemistry; vol. 67; 17; (2014); p. 2843 – 2857;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI