Category: 130-95-0

130-95-0, Quinine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

QN (quinine) 3.24 g (10 mmol) and sodium hydride 0.80 g (200 mmol, respectively) were weighed.2 times equivalent) was added to a three-neck reaction flask. In addition, the air is replaced by argon gas.After replacement, 30 mL of anhydrous tetrahydrofuran (anhydrous) was added under ice bath and argon protection.DMF), after stirring for 1 hour, slowly add dropwise.Add 1.5 mL of benzyl chloride (13 mmol; 1.3 equivalents) and stir while stirring.After the addition is complete, remove the ice bath. After reacting at room temperature for 6 hours, after the reaction is completed,Quenched with saturated ammonium chloride, extracted with ethyl acetate and extracted three times.The upper organic layer was collected, washed twice with water, and once with saturated brine.Dry over anhydrous sodium sulfate, filter, concentrate,Drying gave 3.93 g of a milky white solid 2a in a yield of 95%.

130-95-0, 130-95-0 Quinine 3034034, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Xinxiang Medical University; Wang Yakun; Zhang Tao; Zhang Jixia; Liu Yufei; Li Guowei; Li Nan; (14 pag.)CN108947998; (2018); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.130-95-0,Quinine,as a common compound, the synthetic route is as follows.

General procedure: The alkaloid (12.3 mmol, 1 eq.) and the appropriate substituted benzylic halide derivative(12.3 mmol, 1 eq.) were dissolved in THF (40 mL) with addition of a trace of NaI. The mixture washeated to reflux overnight and then cooled and stirred at ambient temperature for 1 h. In most cases theproduct precipitated as an off-white solid, but where this was not the case and the mixture containedonly a small amount of solid or no solid at all, then diethyl ether (20 mL) was added dropwise.The solid was removed via filtration and washed with THF (50 mL) or ether:THF, (1:1, v/v, 50 mL)and was dried under reduced pressure at 40 C. Where the solid formed was not a fine powder it was then taken up in DCM and this solution was then added dropwise to rapidly stirring ether (100 mL).This usually gives a finely divided solid that could be filtered and dried. (Note: The cinchonine derivedPTCs are usually very insoluble. The quinidine derived PTCs are often completely soluble at the endof the reaction.) The di(t-butyl)benzyl PTC was prepared according to the standard procedure aboveand was filtered directly from the reaction mixture., 130-95-0

130-95-0 Quinine 3034034, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Zhang, Tao; Scalabrino, Gaia; Frankish, Neil; Sheridan, Helen; Molecules; vol. 23; 7; (2018);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

130-95-0, Quinine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example: 11a-(-)-3-(Carbamoylmethyl)-5-methylhexanoic Acid Quinine Salt Aqueous acetone (795ml) was added to the amide II (53 g, 283.42 mmole) at room temperature and the reaction mixture was heated until it became homogenous. Quinine (91 .8 g, 283.42 mmole) was added to the mixture at 80 C. After 15 minutes at this temperature, another batch of quinine (5.3 g, 28.34 mmole) was added to the reaction mixture and heating was continued until the mixture became homogenous. The reaction mixture was allowed to cool down to room temperature. The precipitated solid was filtered, dried and purified to furnish the diastereoisomeric salt of the amide I as a solid which was broken down to obtain enantiomerically enriched amide I; yield: 18 g; 67.9%; HPLC purity: 99.97%., 130-95-0

130-95-0 Quinine 3034034, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Dr. Braja Sundar Pradhan; WO2012/93411; (2012); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.130-95-0,Quinine,as a common compound, the synthetic route is as follows.

To a solution of quinine (78.2 mg, 0.2 mmol) in methanol (10 mL), a solution of ZnCl2 (27.2 mg, 0.2 mmol) in methanol (10 mL) was added. The mixture was stirred and heated at 50C for 2 h, and cooled to room temperature. The resulting solution was treated with aqueous HCl and filtered to remove staring materials. By slow evaporation of the filtrate at room temperature, white single crystals suitablefor X-ray diffraction were obtained after two weeks.The complex was identified as [(Quin)ZnCl3] (I). The yield was 78.8 mg (79.3%). IR (nu, cm-1): 3356 nu(OH), 3074 nu(CHar), 2971nu(CHaliph). For C20H25N2O2Cl3Zn anal. calcd., % C, 48.32 H, 5.07 N, 5.63Found, % C, 48.24 H, 5.02 N, 5.59, 130-95-0

The synthetic route of 130-95-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gu; Jia; Zhang; Russian Journal of Coordination Chemistry; vol. 44; 1; (2018); p. 52 – 58; Koord. Khim.; vol. 44; 1; (2018); p. 52 – 58,7;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI