Category: 137848-29-4

137848-29-4, (S)-2′-Amino-[1,1′-binaphthalen]-2-ol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a 100 ml single-necked flask, 0.74 g of picolinic acid, 1.43 g of (S)-NOBIN and 25 ml of THF were added, and after stirring at room temperature for 10 minutes to fully dissolve, 1.52 g of dehydrating agent DMTMM was added.Continue to stir at room temperature and track by TLC until the raw NOBIN disappears.Add 20 ml of water, stir for 10 min to separate the aqueous layer and extract three times with ether, 20 ml each time.Combine the organic layers and use 5 ml of saturated sodium bicarbonate solution in order.After washing with saturated saline and a 5% dilute hydrochloric acid solution, it was dried over anhydrous sodium sulfate.The crude product after filtration and concentration under reduced pressure was chromatographed on a 25 g silica gel column to obtain 1.75 g of a white amide solid with a yield of 90%.

137848-29-4, 137848-29-4 (S)-2′-Amino-[1,1′-binaphthalen]-2-ol 3617797, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Dalian Institute of Chemical Physics; Hu Xiangping; Hu Xinhu; (10 pag.)CN110551036; (2019); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

137848-29-4, (S)-2′-Amino-[1,1′-binaphthalen]-2-ol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3,5-Di-tert-butylsalicylaldehyde (2.35 g, 10.0 mmol) was mixed with (S)-2-amino-2′-hydroxy-1,1′-binaphthyl (2.85 g, 10.0 mmol) in dry toluene (30 mL). A few 4 A molecular sieves were added, and the solution was warmed up to 70 C and kept for two days at this temperature. The solution was filtered and the solvent was removed under reduced pressure. The resulting yellow oily residue (crude 1) was dissolved in a mixed solvent (40 mL) of methanol and toluene (v/v = 1:3), NaBH4 (2.00 g, 52.6 mmol) was added in small portions at 0 C, then the solution was warmed up to 50 C and kept for 2 h at this temperature. The solvent was removed and the residue was treated with H2O (20 mL) and extracted with ethyl acetate (20 mL ¡Á 3) and washed with brine (20 mL). The combined organic layers were dried with anhydrous Na2SO4 and the solvent was removed under reduced pressure to give a yellow solid, which was further purified by flash column chromatography (hexane/ethyl acetate = 10:1) to give 4H3 as a yellow solid. Yield: 4.75 g (95%).

137848-29-4, The synthetic route of 137848-29-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhao, Ning; Chen, Liang; Ren, Wenshan; Song, Haibin; Zi, Guofu; Journal of Organometallic Chemistry; vol. 712; (2012); p. 29 – 36;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

137848-29-4, (S)-2′-Amino-[1,1′-binaphthalen]-2-ol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 0.100 g (0.351 mmol) of (S)-NOBIN and 0.115 g (0.422 mmol) of 2-benz[a]anthraldehyde-1-ol were refluxed in absolute ethanol (10 mL) under argon for 10 h producing a dark redsolution and precipitate. The mixture was hot-filtered and washed with hot ethanol to produce a dark red solid that was dried in vacuo. Yield of (S)-2: 0.591 g, 81% from (S)-NOBIN. Melting point = 209 C;[alpha]D (20 C) = +126 (c = 1.04, THF); 1HNMR (CDCl3, 400 MHz): d 4.91(s, 1H, OH); 7.31 (d, 1H, J = 3.4 Hz, CH); 7.37 (m, 4H, CH); 7.41 (d, 1H,J = 3.8 Hz, CH); 7.43 (d, 1H, J = 1.8 Hz, CH); 7.61 (m, 4H, CH); 7.71 (d,1H, J = 2.8 Hz, CH); 8.05 (m, 4H, CH); 8.20 (d, 1H, J = 3.4 Hz, CH); 8.31(s, 1H, CH); 8.34 (d, 1H, J = 3.4 Hz, CH); 8.39 (d, 1H, J = 2.2 Hz, CH);8.41 (d, 1H, J = 2.2 Hz, CH); 8.92 (s, 1H, CH); 9.96 (s, 1H, CH); 14.98(s, 1H, OH). 13C NMR (CDCl3, 100 MHz): d 116.15, 116.25, 116.86,118.03, 119.74, 123.87, 124.84, 125.66, 125.82, 126.02, 126.48,126.74, 127.04, 127.14, 127.58, 128.00, 128.63, 128.76, 128.97,129.60, 129.78, 129.95, 130.61, 131.12, 131.24, 131.31, 131.33,132.85, 133.02, 133.80, 133.89, 137.33, 143.84, 151.39, 161.18,164.04. TOF-MS (m/z): [M]+ Calcd for C39H25O2N1 540.184, found 540.115. Anal. Calc. for C39H25O2N1: C, 86.80; H, 4.67; N, 2.60. Found:C, 86.59; H, 4.51; N, 2.43%. Single crystals suitable for X-ray analysis were grown by slow diffusion of hexane into a methylene chloride solution of (S)-2., 137848-29-4

As the paragraph descriping shows that 137848-29-4 is playing an increasingly important role.

Reference£º
Article; Barman, Sanmitra; Desper, John; Levy, Christopher J.; Polyhedron; vol. 84; (2014); p. 168 – 176;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI