Category: 13910-48-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13910-48-0,N1-Benzylpropane-1,3-diamine,as a common compound, the synthetic route is as follows.

c) methyl [(4Z)-4-(4-benzyl-l,4-diazepan-2-ylidene)-l-(2-chlorophenyl)-5-oxo-4,5- dihydro-lH-pyrazol-3-yl] acetate Compound of Formula (II), Scheme 1)To a solution of the above obtained methyl [4-(chloroacetyl)-l-(2-chlorophenyl)-5- hydroxy-lH-pyrazol-3-yl]acetate (Compound of Formula (V), 1.88 mmol, 1 eq.) in 3 mL of acetonitrile was added, slowly at zero degree Celsius, N-benzylpropane-l ,3-diamine (0.277 mg, 0.9 eq.). The reaction mixture was stirred at 0C for 0.5 h. The resulting solution was purified by silica plug using ethylacetate/0.1% triethylamine. The solvent was evaporated in vacuo and allowed to isolate a red solid which proved to be the pure methyl [(4Z)-4-(4- benzyl-l,4-diazepan-2-ylidene)-l-(2-chlorophenyl)-5-oxo-4,5-dihydro-lH-pyrazol-3-yl] acetate (0.530 g). Yield 71 %. MS(ESI+): 454.0., 13910-48-0

13910-48-0 N1-Benzylpropane-1,3-diamine 83811, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; GENKYOTEX SA; PAGE, Patrick; GAGGINI, Francesca; LALEU, Benoit; WO2011/36651; (2011); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

13910-48-0, N1-Benzylpropane-1,3-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-(4-tert-butylphenyl) -4-(methylsulfanyl) -6H,7H-pyrazolo [1,5 -aj [1,3 ,5j triazin-7 -one(75 mg, 0.239 mmol) and (3-aminopropyl)(benzyl)amine (117 mg, 0.71 mmol) were dissolved in Pyridine (1 mL). The reaction mixture was heated in a microwave at 140 C for2h. The reaction mixture was evaporated to dryness and purified by preparative HPLC method A affording the title compound as a pale yellow oil (35 mg, 34 %).?H NMR (500 MHz, Methanol-d4) 8.36 (s, 2H), 8.29 – 8.20 (m, 2H), 7.56 – 7.46(m, 2H), 7.44 -7.30 (m, 5H), 5.70 (s, 1H), 4.15 (s, 2H), 3.83 (t, I = 6.3 Hz, 2H), 3.24 -3.08 (m, 2H), 2.18 (dt, I = 14.2, 6.5 Hz, 2H), 1.37 (s, 9H). LCMS Method B: ft 2.44 mm, 100 %; m/z 432 (MH)., 13910-48-0

The synthetic route of 13910-48-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; EVOTEC INTERNATIONAL GMBH; GAMPE, Christian, M.; KAHNE, Daniel, Evan; KAHNE, Suzanne, Walker; QIAO, Yuan; EAST, Stephen; PARKES, Alastair, L.; SOUTHEY, Michelle; HUNTER, James; WHITTAKER, Mark; ARTHUIS, Martin; (359 pag.)WO2016/191658; (2016); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

13910-48-0, N1-Benzylpropane-1,3-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Pyrazolone 1b (643 mg, 1.88 mmol) was dissolved in CH3CN (10 mL) and amine 2N-benzylpropane-1,3-diamine was added at 0 C under N2. The reaction mixture was stirred at 0 C for 3 h and monitored by LC-MS showing 40% of starting material left. Then DIPEA (two drops) was added and the mixture was stirred at RT for 1 h: LC-MS showed completely conversion of starting material into desired product. The solvent was concentrated in vacuo until dryness. The residue was dissolved in ethylacetate (10 mL), washed with saturated NaHCO3 solution (5 mL * 2), dried over Na2SO4 and concentrated. The crude product was used in the following step without further manipulation (530 mg, 71% yield, 86% HPLC purity, LC-MS (M+H)+: 453.4).

13910-48-0, 13910-48-0 N1-Benzylpropane-1,3-diamine 83811, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Gaggini, Francesca; Laleu, Benoit; Orchard, Mike; Fioraso-Cartier, Laetitia; Cagnon, Laurne; Houngninou-Molango, Sophie; Gradia, Angelo; Duboux, Guillaume; Merlot, Cedric; Heitz, Freddy; Szyndralewiez, Cedric; Page, Patrick; Bioorganic and Medicinal Chemistry; vol. 19; 23; (2011); p. 6989 – 6999;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI