Extracurricular laboratory:new discovery of (S)-4-(tert-Butyl)-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole

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Progress towards the total synthesis of hamigerans C and D: A direct approach to an elaborated 6-7-5 carbocyclic core

The hamigeran family of natural products has been the target of numerous synthetic efforts because of its biological activity and interesting structural properties. Herein, we disclose our efforts toward the synthesis of hamigerans C and D, unique among the initially isolated members because of their 6-7-5 carbocyclic core. Our approach directly targets this tricyclic motif by sequential Negishi and Heck coupling reactions, yielding an advanced intermediate with all necessary carbons and sufficient functionality poised for completion of the synthesis of these two natural products.

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Metal catalyst and ligand design,
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Synthesis of the A-D Ring System of the Gambieric Acids

The A-D fragment of gambieric acids A and C has been synthesized using an asymmetric Tsuji-Trost allylation reaction to couple the two key segments. The A ring fragment has been prepared by a short and highly efficient route involving diastereoselective Lewis acid mediated alkylation of an acetal. Iterative ring-closing metathesis reactions have been used to construct cyclic ethers and assemble the tricyclic B-D fragment.

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Metal catalyst and ligand design,
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Short Enantioselective Formal Synthesis of (-)-Platencin

A short enantioselective formal synthesis of the antibiotic natural product platencin is reported. Key steps in the synthesis include enantioselective decarboxylation alkylation, aldehyde/olefin radical cyclization, and regioselective aldol cyclization.

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Metal catalyst and ligand design,
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Short Enantioselective Formal Synthesis of (-)-Platencin

A short enantioselective formal synthesis of the antibiotic natural product platencin is reported. Key steps in the synthesis include enantioselective decarboxylation alkylation, aldehyde/olefin radical cyclization, and regioselective aldol cyclization.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

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Total synthesis of (+)-kopsihainanine A

Total synthesis of (+)-kopsihainanine A was accomplished on the basis of (i) Stoltz’s enantioselective decarboxylative asymmetric allylation and (ii) the proposed biogenetic pathway from the related alkaloid, kopsihainanine B. In addition, HPLC analysis of the synthetic (+)-kopsihainanine A confirmed its ee to be 99% with [alpha]30D = 25.35. the Partner Organisations 2014.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Archives for Chemistry Experiments of (S)-4-(tert-Butyl)-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Quality Control of: (S)-4-(tert-Butyl)-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 148461-16-9, Name is (S)-4-(tert-Butyl)-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole, molecular formula is C25H26NOP. In a Article, authors is Gao, Yanfeng£¬once mentioned of 148461-16-9

New spiro phosphinooxazolines for palladium-catalyzed asymmetric allylic amination

The new conformational rigid spiro phosphinooxazolines 1 were synthesized from 7-bromo-1-indanone. The asymmetric catalytic potential of them was demonstrated in the asymmetric palladium catalyzed allylic amination. High yields and enantioselectivities were obtained with alkylamines.

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Metal catalyst and ligand design,
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Brief introduction of 148461-16-9

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Enantioselective palladium-catalyzed decarboxylative allylation of carbazolones: Total synthesis of (-)-aspidospermidine and (+)-kopsihainanineA

Functionalized chiral carbazolones with alpha-quaternary carbon centers are formed through the ligand-controlled Pd-catalyzed enantioselective decarboxylative allylic alkylation of carbazolones (see scheme). This catalytic asymmetric reaction was employed as the key step in the total synthesis of aspidospermidine and (+)-kopsihainanineA. Copyright

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI