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The present invention is directed to nanoparticulate compositions comprising megestrol. The megestrol particles of the composition have an effective average particle size of less than about 2000 nm.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

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The inclusional process of decyltrimethylammonium bromide (DTAB) into the cavity of beta-cyclodextrin (beta-CD) has been studied by measuring speed of sound (u) of aqueous solutions of DTAB in the presence of various constant concentrations of beta-cyclodextrin at 298.15 K.The predominant complex formed has a stoichiometry of 1:1.The apparent critical micellar concentrations, cmc* (the cmc for the system DTAB + beta-CD + H2O), is found to increase upon the addition of cyclodextrin, while the concentration of free surfactant available for the micellization process in the presence of beta-CD (f) increases slightly.The binding or association constant of the complexation equilibrium is evaluated from u measurements by using a nonlinear regression method.The resulting K value is analyzed and compared with those given by other researchers and the discrepancies are discussed.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

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The inhibitory activities of four new homologous series of organic ammonium salts (OAS) were tested on bacterial strains isolated from patients. Two types of compounds were used: ‘hard’ (group A) and three groups (B, C, D) of biodegradable ‘soft’ OAS with metabolically labile CO or NH groups in their molecules. The strain Pseudomonas aeruginosa was isolated from the sputum of a patient with carcinoma. The strain Salmonella typhimurium was isolated from a patient with clinical diagnosis of diarrhea. In all homologous series, the antibacterial activity was increasing continuously with the length of alkyl chain up to dodecyl or tetradecyl, then the ‘cut off’ effect was observed. The most active compounds from both ‘hard’ and ‘soft’ types had superior activity to commercial disinfectants. The strain of Pseudomonas aeruginosa was more sensitive to these compounds than that of Salmonella typhimurium.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

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The interactions between bisphenol A (BPA) and cationic surfactant micelles have been studied by interfacial tension (gamma), conductivity (kappa) and pyrene fluorescence intensity (I1/I3) measurements. The following cationic surfactants have been investigated: decyltrimethylammonium bromide (DeTAB), dodecyltrimethylammonium bromide (DTAB), tetradecyltrimethylammonium bromide (TTAB) and hexadecyltrimethylammonium bromide (HTAB). As the BPA concentration increases, the critical micelle concentration (cmc) and the maximum surface excess (Gammamax) of surfactant decreases. Both the effects are more pronounced at smaller concentration of BPA, and also for the surfactant with a longer hydrocarbon tail. The degree of micelle dissociation (alpha) tends to decrease with an increase of hydrocarbon tail length of surfactant molecule, except for the shortest chain DeTAB. Considering the ionic association constant (KA), however, the KA value increases with the increase of hydrocarbon chain including DeTAB. That is to say, the anomalously small alpha value of DeTAB could be caused by its large cmc. As for the dependence of alpha value on BPA, the alpha value is increased by BPA addition in all the surfactants. The standard free energies of micellization (Delta Gm0) and of interfacial adsorption (Delta Gad0) have also been determined. Those values indicate that BPA stabilizes the surfactant molecules in the micelle and at the air/water interface. These stabilizations are larger at the interface than in the micelle, which appears more significantly with the surfactant of longer hydrocarbon tail. From the fluorescence measurements, the I1/I3 ratio shows almost no change with the increase of BPA concentration above the cmc. This means that the environmental polarity of pyrene is not affected by BPA in the micelle.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

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Although enzymes are highly efficient and selective catalysts, there have been problems incorporating them into fuel cells. Early enzyme-based fuel cells contained enzymes in solution rather than immobilized on the electrode surface. One problem utilizing an enzyme in solution is an issue of transport associated with long diffusion lengths between the site of bioelectrocatalysis and the electrode. This issue drastically decreases the theoretical overall power output due to the poor electron conductivity. On the other hand, enzymes immobilized at the electrode surface have eliminated the issue of poor electron conduction due to close proximity of electron transfer between electrode and the biocatalyst. Another problem is inefficient and short term stability of catalytic activity within the enzyme that is suspended in free flowing solution. Enzymes in solutions are only stable for hours to days, whereas immobilized enzymes can be stable for weeks to months and now even years. Over the last decade, there has been substantial research on immobilizing enzymes at electrode surfaces for biofuel cell and sensor applications. The most commonly used techniques are sandwich or wired. Sandwich techniques are powerful and successful for enzyme immobilization; however, the enzymes optimal activity is not retained due to the physical distress applied by the polymer limiting its applications as well as the non-uniform distribution of the enzyme and the diffusion of analyte through the polymer is slowed significantly. Wired techniques have shown to extend the lifetime of an enzyme at the electrode surface; however, this technique is very hard to master due to specific covalent bonding of enzyme and polymer which changes the three-dimensional configuration of enzyme and with that decreases the optimal catalytic activity. This chapter details encapsulation techniques where an enzyme will be immobilized within the pores/pockets of the hydrophobically modified micellar polymers such as Nafion and chitosan. This strategy has been shown to safely immobilize enzymes at electrode surfaces with storage and continuous operation lifetime of more than 2 years.

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Metal catalyst and ligand design,
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A lanthanum-containing polyoxometalate (POM) of DA11[La(PW 11O39)2] (denoted as DA-La(PW 11)2; DA = Decyltrimethylammonium cation) is highly efficient and selective for oxidation of various substrates including alkenes, alkenols, sulfides, silane and alcohol with only one equiv. H2O 2 as oxidant at 25 C, and the POM catalyst can be easily recovered and reused for ten times without obvious decrease of catalytic activity and the yields for catalyst recovery are all above 95%. The epoxidation of cis-cyclooctene proceeds efficiently in 98% yield with only 0.08 mol% of DA-La(PW11)2, and the turnover number (TON) can reach as high as 1200 at 25 C.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

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A direct spectrophotometric determination of DNA in solution has been developed using a near infrared probe, 1,1?-disulfobutyl-3,3,3?, 3?-tetramethylindotricarbocyanine (DSTCY). In pH = 7.5 Tris-HCl buffer, the reaction of DSTCY with DNA was complete within 10 min at room temperature in the presence of cetyltrimethylammonium bromide (CTAB), which leaded to a sharp increase of the absorbance at 474 nm. The concentration of DNA can be determined in such wavelength with the linear range of 0.5-8.0 mug ml-1 and the detection limit of 45 ng ml-1.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

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Hypothesis Emerging applications of carbohydrate/cationic surfactant mixtures require not only synergistic mixing, but also accessible sugar headgroups at the exterior of micelles. A previous study showed that the glucoside headgroups of octyl-beta-D-glucopyranoside aggregate at the interior of mixed micelles with equimolar cetyltrimethylammonium bromide rather than mixing with trimethylammonium groups at the corona. The current study tests the hypothesis that structural characteristics of the surfactants (the relative lengths of the alkyl tails and the type of linker) can be tuned to shift the carbohydrate groups to micelle surfaces. Experiments The structural arrangement of 30 mM equimolar mixed micelle solutions in D2O is investigated using NMR. The dynamics in different regions are probed using 1H spin-lattice (T1) and spin-spin (T2) relaxation measurements, and relative positioning by nuclear Overhauser effect spectroscopy (NOESY). Additional micellar properties are determined using solvatochromic fluorescent probes. Findings Matching surfactant alkyl tail lengths is found ineffective at ?pushing out? the carbohydrate headgroups due to a large mismatch in interactions between the headgroups and D2O. However, inserting a novel polar triazole group between the carbohydrate head group and the hydrophobic tail (e.g. in n-octyl-beta-D-xylopyranoside) using click chemistry is able to ?pull out? the carbohydrate, thus giving accessible sugar moieties at the surface of mixed micelles.

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Reference:
Metal catalyst and ligand design,
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A detailed study of the adsorption of the n-alkyltrimethylammonium bromides (CnTAB) to lysozyme by measurements of the zeta potential (zeta-potential) has been realized as a function of concentration and pH.While at pH 3.2 the zeta-potential of lysozyme remains positive in the presence of surfactants, at pH 7 and 10 the alkylammonium ions affect the zeta-potential causing a change in the neighbourhood of the point of zero charge (pzc) from negative to positive values.From the pzc we have calculated Gibbs energies of adsorption and compared them with Gibbs energies of binding determined by equilibrium dialysis.The results are similar, showing that the zeta-potential technique can be useful in a study of the interactions of proteins with amphiphilic ligands.

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Metal catalyst and ligand design,
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The adiabatic compressibility of aqueous solutions of octyl-, decyl-, dodecyl- and tetradecyl-trimethylammonium bromides has been determined from measurements of density and ultrasound velocity at different temperatures ranging from 20 to 45 deg C at 5 deg C intervals.Based on the theoretical treatment in which the adiabatic compressibility is given as a function of concentration, the apparent adiabatic compressibilities of the surfactant in the monomeric (beta1) and micellar (betam) forms are obtained from the experimental results at each temperature.The values for beta1 increase with increased temperature, and its temperature coefficient is constant for methyl, octyl and decyl derivatives, but changes sharply between 30 and 40 deg C for the dodecyl and tetradecyl derivatives.The value of betam increases linearly with increased temperature, and its temperature coefficient increases with increasing alkyl chain length.The linear changes of beta1 and betam with temperature are related to the change of hydrophilic hydration, while the sharpe change of beta1 for dodecyl and tetradecyl derivatives is attributed to the change of hydrophobic hydration.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI