Category: 2304-30-5

2304-30-5, Tetrabutylphosphonium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation of Tetrabutylphosphonium Tetrafluoroborate:; Tetrabutylphosphonium chloride was added into an aqueous solution with excessive amount of sodium tetrafluoroborate (molar ratio: 1/1.1) and stirred for 24 hours. Then, adequate amount of methylene dichloride was added to extract the product. A mixture of the product and the methylene dichloride was washed with water until no chlorine ion was detected by a silver nitrate solution (0.1 mol/L). A product of tetrabutylphosphonium tetrafluoroborate was obtained after removing methylene dichloride in the product by rotary evaporation and drying., 2304-30-5

The synthetic route of 2304-30-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; INSTITUTE OF PROCESS ENGINEERING, CHINESE ACADEMY OF SCIENCES; US2011/21846; (2011); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2304-30-5,Tetrabutylphosphonium chloride,as a common compound, the synthetic route is as follows.

EXAMPLE 1 Preparation of 2,4,6-tris(o-aminophenylthiomethyl)mesitylene A 2-liter glass reaction vessel equipped with a Teflon stirrer, reflux condenser, addition funnel, 2-thermometers and an electrical heater was charged with 243 g water and 104.2 g sodium hydroxide pellets. After boiling under a nitrogen atmosphere for 5 minutes, 167.8 g benzothiazole was gradually added to the contents of the reactor over 50 minutes. The resultant mixture was then heated at the boiling point for 2 hours. A solution of 0.5 g tetrabutyl phosphonium chloride (50% in toluene) and 50 g toluene was then added, which cooled the reaction mixture to 90 C. A solution of 100 g 2,4,6-tris(chloromethyl)mesitylene in 300 g of warm toluene was added over a 15 minute period and the resultant mixture was heated at the boiling point for 2 hours. The aqueous phase of the reaction mixture was then removed and the organic phase washed with 100 g hot water. The residual water was removed by azeotropic distillation. After being filtered the toluene solution gradually cooled to room temperature, during which time a slightly off-white solid crystallized. The solid was filtered off, washed sequentially with cold toluene and heptane and then dried under reduced pressure at 90 C. The product weighed 164.7 g melted from 161 to 166 C. and exhibited an amine equivalent of 181. The theoretical amine equivalent for the expected product, 1,3,5-tris(o-aminophenylthiomethyl)mesitylene is 178.

2304-30-5, As the paragraph descriping shows that 2304-30-5 is playing an increasingly important role.

Reference£º
Patent; M&T Chemicals Inc.; US4187250; (1980); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2304-30-5,Tetrabutylphosphonium chloride,as a common compound, the synthetic route is as follows.

2. Preparation of 2-Chlorosulfonyl-7-fluoro-5-methoxy-[1,2,4]triazolo[1,5-c]pyrimidine A mixture of 5.0 g (13 mmol) of 2,2′-dithiobis-(7-fluoro-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidine), 75 mL of dichloromethane, 25 mL of water, and 0.3 g (1.0 mmol) tetrabutylphosphonium chloride was cooled to 3 C. and 6.0 g (8.5 mmol) of chlorine gas was added with stirring and cooling. The mixture was allowed to react at 0 to 3 C. with stirring for 2 hours by which time the initial slurry had become clear leaving two liquid phases. The phases were separated and the organic phase was concentrated by evaporation under reduced pressure to obtain 7.5 g of the title compound in impure form as a white solid. 1 H NMR Spectrum (300 MHz) in CDCl3: 6.96(s, 1 H), 5.29(s, 1 H), 4.40(s, 3 H)., 2304-30-5

The synthetic route of 2304-30-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Dow AgroSciences LLC; US6162915; (2000); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

2304-30-5, Tetrabutylphosphonium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

200 g (0.68 mol) of tetra-n-butylphosphonium chloride,In an aqueous solution containing 80% of potassium formate was added 84 g (1.00 mol)Was added to the solution.In this state, since two phases were separated, water was added to make a homogeneous solution.This solution was concentrated under reduced pressure at 100 C.,Crystals of potassium chloride precipitated.The crystals were hot-filtered, and the filtrate containing the ionic liquid was recovered.The filtrate was dried under reduced pressure with an oil rotary pump to recover the regenerated ionic liquid.When this ionic liquid was analyzed by the Mohr method, the chloride ion concentration was 0.37 mol / kg.That is, it was found that 89% of the chloride ion in the model degraded ionic liquid was removed and replaced with formate ion.

2304-30-5, 2304-30-5 Tetrabutylphosphonium chloride 75311, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; The Doshisha; Yasaka, Yoshiro; (11 pag.)JP2015/113335; (2015); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

2304-30-5, Tetrabutylphosphonium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,2304-30-5

EXAMPLE 2 2-Benzylthio-5-chlorophenylisonitrile A reaction flask was charged under a nitrogen atmosphere with 6 g (0.03 mole) of 2-mercapto-5-chloroaniline hydrochloride, 4 g (0.03 mole) of benzyl chloride, 5 ml of 50% aqueous sodium hydroxide, and 250 mg of tetra-n-butylphosphonium chloride. The mixture was heated to reflux for two hours, and 3 ml each of benzene and water were added. The organic phase was then washed with a 10% caustic solution and evaporated to yield 8.1 g of a black oil, confirmed by mass spectroscopy to be 2-benzylthio-5-chloroaniline. A reaction flask was then charged with 6 g (0.02 mole) of this product, 5 ml of chloroform, 10 ml of methylene chloride, 10 ml of 50% aqueous sodium hydroxide solution, and 100 mg of benzyltriethylammonium chloride. The procedure of Example 1 was then followed, producing 6 g of a black oil, which was passed through an alumina chromatography column with hexane, followed by a hexane-benzene mixture.

2304-30-5 Tetrabutylphosphonium chloride 75311, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Stauffer Chemical Company; US4380468; (1983); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2304-30-5,Tetrabutylphosphonium chloride,as a common compound, the synthetic route is as follows.

EXAMPLE 4 27.35 g of 3-methyl-3-chloro-2-(2′,2′-dichlorovinyl)-butanecarboxylic acid ethyl ester in the form of the crude solution prepared in Example 1 were dissolved in 50 ml of toluene. 2 g of tetrabutylphosphonium chloride were added and 16.8 g of 50% strength potassium hydroxide solution were then added dropwise at 0 C. The solution was subsequently stirred until it had reached room temperature and was then stirred for a further 1 hour at 35 C. It was then diluted with ice-water and rendered neutral and the organic phase was separated off and fractionated. This gave 21.9 g (92.5% of theory) of 2,2-dimethyl-3-(2′,2′-dichlorovinyl)-cyclopropanecarboxylic acid ethyl ester., 2304-30-5

2304-30-5 Tetrabutylphosphonium chloride 75311, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Bayer Aktiengesellschaft; US4217300; (1980); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

2304-30-5, Tetrabutylphosphonium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The same procedure described above for the preparation of [nBu4P][PtBr3(C2H4)] was adopted, except for the use of PtCl2 (100.2 mg, 0.38 mmol) and nBu4PCl (102.4 mg, 0.38 mmol), with the addition of 10 mL of dry toluene. Yield: 148.4 mg, 66%. 1H NMR (CDCl3): delta 4.48 (s + d, JPt-H = 64.3 Hz, 4H, C2H4), 2.30 (m, 8H, br, PCH2), 1.60 (m, 4, br, CH2CH2), 1.05 (m, 3, br, CH3). 31P{1H} NMR: delta 33.14. 195Pt NMR: delta -2743(quint 2JPt-H = 64 Hz). Anal. % Calcd. for C18H40Cl3PPt (M = 588.930): C, 36.71; H, 6.85. Found: 37.2; H, 6.9., 2304-30-5

As the paragraph descriping shows that 2304-30-5 is playing an increasingly important role.

Reference£º
Conference Paper; Bethegnies, Aurelien; Poli, Rinaldo; Journal of Organometallic Chemistry; vol. 730; (2013); p. 165 – 167;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2304-30-5,Tetrabutylphosphonium chloride,as a common compound, the synthetic route is as follows.

A stirred solution of sodium 2,2-dimethyl-N,N-dichlorotaurine (35 g, 143 mmol) in 175 mL of water was treated with a solution of tetrabutylphosphonium chloride (38 g, 129 mmol) in 175 mL of water. The resulting suspension was stirred 10 min then 400 mL of ethyl acetate was added and the mixture was stirred vigorously. After separation of the layers, the aqueous layer was extracted with 2¡Á200 mL of ethyl acetate. The combined organic layers were dried over sodium sulfate and filtered. The sodium sulfate pad was washed with 2¡Á100 mL of ethyl acetate. The filtrate was concentrated to dryness and placed under high vacuum overnight (0.4 torr)to constant weight which provided 2,2-dimethyl-N,N-dichlorotaurine tetrabutylphosphonium (59.9 g, 96.6%) as a white solid, mp 118-120 C. 1H NMR (CDCL3) 3.34 (s, 2H); 2.33 (q, 8H); 1.65 (s, 6H); 1.54 (m, 16H); 0.99 (t, 12H)., 2304-30-5

The synthetic route of 2304-30-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ALCON RESEARCH, LTD.; US2009/197838; (2009); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI