Category: 23616-79-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23616-79-7,N-Benzyl-N,N-dibutylbutan-1-aminium chloride,as a common compound, the synthetic route is as follows.

Reference Example 3 Potassium carbonate (414 g) is suspended in chloroform (1.3 l), and thereto is added dropwise water (29 ml) gradually. To the mixture are added tributylbenzylammonium chloride (37 g), 2′,6′-dihydroxy-4′-methylacetophenone (100 g), and 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide (419 g), and the mixture is stirred at room temperature for 27 hours. To the mixture is added water (21 ml), and the mixture is stirred for further 2.5 hours. The mixture is neutralized with 18% hydrochloric acid (about 500 ml) under ice-cooling. To the mixture are added 18% hydrochloric acid (about 200 ml) and water (500 ml), and the chloroform layer is separated, washed with water and a saturated aqueous sodium chloride solution, dried, and concentrated. To the residue is added methanol (400 ml), and the mixture is concentrated under reduced pressure to about a half volume thereof. To the resultant is added methanol (2 l), and the mixture is heated a little, and stirred under ice-cooling for 30 minutes. The precipitates are collected by filtration, and dried under reduced pressure to give 2′-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyloxy)-6′-hydroxy-4′-methylacetophenone (239.75 g). The physicochemical properties of the compound are the same as those of the compound obtained in Reference Example 2.

23616-79-7, As the paragraph descriping shows that 23616-79-7 is playing an increasingly important role.

Reference£º
Patent; Tanabe Seiyaku Co., Ltd.; US6048842; (2000); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

23616-79-7, N-Benzyl-N,N-dibutylbutan-1-aminium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 82 A mixture of 3-[3-methoxy-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]propionaldehyde (1.79 g), sodium cyanide (0.3 g), acetic anhydride (0.62 g), benzyltributylammonium chloride (0.79 g), water (12 ml) and dichloromethane (35 ml) was stirred for 15 hours at room temperature. The organic layer was separated, which was washed with water and dried (MgSO4), followed by distilling off the solvent. The resulting oily product was subjected to column chromatography on silica gel. From the fraction eluted with ethyl acetate-hexane (1:3, v/v), was obtained 2-acetoxy-4-[3-methoxy-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]butyronitrile (2.0 g, 94%), NMR(delta ppm in CDCl3): 2.14(3H,s), 2.12-2.31(2H,m), 2.41(3H,s), 2.78(2H,t,J=8 Hz), 3.87(3H,s), 5.04(2H,s), 5.27(1H,t,J=7 Hz), 6.70(1H,dd,J=8&2 Hz), 6.71(1H,d,J=2 Hz), 7.00(1H,d,J=9 Hz), 7.42-7.47(3H,m), 7.99-8.04(2H,m), 23616-79-7

23616-79-7 N-Benzyl-N,N-dibutylbutan-1-aminium chloride 159952, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; US5932601; (1999); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

23616-79-7, N-Benzyl-N,N-dibutylbutan-1-aminium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

23616-79-7, REFERENCE EXAMPLE 5 To a mixture of 4-[4-[(5-methyl-2-phenyl-4-thiazolyl)methoxy]phenyl]butylaldehyde (4.68 g), benzyl tributylammonium chloride (2.07 g), ethyl acetate (150 mL) and water (30 mL) was added sodium cyanide (650 mg) at room temperature. After stirring for 1.5 hr at room temperature, 2N hydrochloric acid (10 mL) was added to the reaction mixture to make the mixture acidic. The ethyl acetate layer was separated, washed successively with water (80 mL) and saturated brine (50 mL) and dried (MgSO4). The solvent was evaporated under reduced pressure, and the residue was subjected to silica gel column chromatography and eluted with hexane-ethyl acetate (2:1, v/v) to give 2-hydroxy-5-[4-[(5-methyl-2-phenyl-4-thiazolyl)methoxy]phenyl]pentanenitrile (4.22 g, 84%). Recrystallization from ethyl acetate-hexane gave a colorless prism crystal. melting point: 101-102 C.

As the paragraph descriping shows that 23616-79-7 is playing an increasingly important role.

Reference£º
Patent; Hazama, Masatoshi; Miyazaki, Takeshi; Sugiyama, Yasuo; US2003/134884; (2003); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23616-79-7,N-Benzyl-N,N-dibutylbutan-1-aminium chloride,as a common compound, the synthetic route is as follows.

EXAMPLE 3 A 3-necked, 250 mL round-bottomed flask equipped with a reflux condenser and two pressure equalizing addition funnels was charged with 60 mL of a 30 percent by weight aqueous sodium hydroxide solution and 1.275 gram (4.1 mmol) of benzyltributylammonium chloride. 4-hydroxymethyl-2-methoxy-2-methyl-1,3-dioxolane (29.14 g, 196.7 mmol) and 25 g vinylbenzyl chloride (164 mmol) were simultaneously charged under a nitrogen atmosphere from the addition funnels into the flask over a 5 minute period. The reaction flask was immersed in an oil bath at 50 C. and the contents were stirred for 6 hours, then stirred at room temperature overnight. The organic phase was separated, diluted with methylene chloride (200 mL) and triethylamine (5 mL), washed with water, dried over anhydrous magnesium sulfate, and vacuum stripped. 42 g of 4-hydroxymethyl-2-methoxy-2-methyl-1,3-dioxolane vinylbenzyl ether were produced.

23616-79-7, 23616-79-7 N-Benzyl-N,N-dibutylbutan-1-aminium chloride 159952, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; General Electric Company; US5231197; (1993); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

23616-79-7, N-Benzyl-N,N-dibutylbutan-1-aminium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

b N-{5-(4-Chlorophenyl)pent-1-en-4-yl}-N-ethoxymethyl-3,5-dimethylbenzamide 2.36 ml (25.2 mmol) of chloromethyl ethyl ether are added in small portions over the course of 2 hours to a vigorously stirred solution of 5.5 g (16.8 mmol) of N-{5-(4-chlorophenyl)pent-1-en-4-yl}-3.5-dimethylbenzamide and 100 mg of benzyltributylammonium chloride in 15 ml of 50% strength aqueous sodium hydroxide solution and 15 ml of dichloromethane at 0-50. The organic phase is taken up in dichloromethane and water, the organic phase is separated off, dried over sodium sulfate and evaporated to dryness under reduced pressure. The oily residue is purified by chromatography on silica gel with ethyl acetate/hexane (1:4) as mobile phase; TLC (ethyl acetate/hexane; 1:3): Rf =0.50; 1H-NMR (300 MHz, CDCl3): mixture of rotamers, delta=7.31-7.18 (m, 4H), 7.04-6.85 (m, 2.6H), 6.42 (br. s, 0.4H), 5.92-5.60 (m, 1H), 5.20-5.02 (m, 2H), 4.54-4.24 (m, 2H), 3.96-3.67 (m, 1H), 3.25-2.40 (m, 6H), 2.28 (s, ca 5H), 2.24 (s, ca 1H), 1.34-1.21 (m, ca 0.5H), 1.08 (t, J=7, ca 2.5 H).

23616-79-7, 23616-79-7 N-Benzyl-N,N-dibutylbutan-1-aminium chloride 159952, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Patent; Ciba-Geigy Corp.; US5310743; (1994); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI