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Quaternary ammonium drugs (QADs) are anticholinergic agents some of which are known to have been abused or misused in equine sports. A recent review of literature shows that the screening methods reported thus far for QADs mainly cover singly-charged QADs. Doubly-charged QADs are extremely polar substances which are difficult to be extracted and poorly retained on reversed-phase columns. It would be ideal if a comprehensive method can be developed which can detect both singly- and doubly-charged QADs. This paper describes an efficient liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for the simultaneous detection and confirmation of 38 singly- and doubly-charged QADs at sub-parts-per-billion (ppb) to low-ppb levels in equine urine after solid-phase extraction.Quaternary ammonium drugs were extracted from equine urine by solid-phase extraction (SPE) using an ISOLUTE CBA SPE column and analysed by LC/MS/MS in the positive electrospray ionisation mode. Separation of the 38 QADs was achieved on a polar group embedded C18 LC column with a mixture of aqueous ammonium formate (pH 3.0, 10mM) and acetonitrile as the mobile phase. Detection and confirmation of the 38 QADs at sub-ppb to low-ppb levels in equine urine could be achieved within 16min using selected reaction monitoring (SRM). Matrix interference of the target transitions at the expected retention times was not observed. Other method validation data, including precision and recovery, were acceptable. The method was successfully applied to the analyses of drug-administration samples.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

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Several alkyl-, aralkyl-, and aryl-substituted diammonium mu-oxobis salts, of potential interest as model compounds for the study of certain electrophysical and biological processes, are synthesized via the corresponding tetrachloroferrate(III) salts and are characterized by IR and Raman spectroscopy.A structure analysis is performed on the representative bis(benzyldimethylphenylammonium) mu-oxobis(trichloroferrate).The (tetracoordinate) iron atoms in the oxo-bridged dinuclear anoin of the salt each possess an ever so slightly distorted tetrahedral ligand environment; the bridge geometry compares well with that of other salts containing the 2- anion.Crystallographic Data: a = 26.392(5) Angstroem, b = 14.015(3) Angstroem, c = 9.638(2) Angstroem, beta = 92.65(2) deg, and Z = 4; space group P21/n.R(F) = 0.070, Rw(F) = 0.078 for 4447 observed reflections.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

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The application of ternary and multicomponent complexes in spectrophotometric and spectrofluorimetric determination of trace elements is reviewed. Newer types of colour systems employing mixed ligand, surfactant sensitized, ion-association, flotation, derivative and FIA systems are described. Separate sections are devoted to advances in both spectrophotometric and spectrofluorimetric determination of individual elements. Future trends in spectrophotometric and spectrofluorimetric analysis are discussed.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

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There is provided a two-pack epoxy resin composition that is excellent in viscosity stability at a low temperature (40C) of an epoxy resin composition after mixing preparation, retains low viscosity at the time of injection into reinforcing fiber and is excellent in impregnation property, and controls resin flow by appropriate increase in the resin viscosity after the impregnation, for example, can reduce burrs on the formed product, cures in a short time at the time of formation, and gives a fiber-reinforced composite material high in transparency of a cured product and excellent in formed product quality, and a fiber-reinforced composite material made by using the same.The two-pack epoxy resin composition for a fiber-reinforced composite material of the present invention is a two-pack epoxy resin composition for a fiber-reinforced composite material containing the following components [A] to [E], in which the content of the component [A] is 5 to 45 parts by mass, the content of the component [B] is 5 to 50 parts by mass, and the content of the component [C] is 5 to 50 parts by mass, relative to 100 parts by mass of the total of the components [A], [B] and [C], and the fiber-reinforced composite material of the present invention is a fiber-reinforced composite material obtained by combining the two-pack epoxy resin composition for a fiber-reinforced composite material and a reinforcing fiber, and curing them. ? component [A]: an alicyclic epoxy resin ? component [B]: an aliphatic epoxy resin ? component [C]: a bisphenol type epoxy resin ? component [D]: an acid anhydride ? component [E]: a compound selected from the group consisting of quaternary ammonium salts, quaternary phosphonium salts, and imidazolium salts.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

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Semi-aqueous compositions useful for the selective removal of titanium nitride and/or photoresist etch residue materials relative to metal conducting, e.g., tungsten and copper, and insulating materials from a microelectronic device having same thereon. The semi-aqueous compositions contain at least one oxidant, at least one etchant, and at least one organic solvent, may contain various corrosion inhibitors to ensure selectivity.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

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Montmorillonite (Mt) resol, and Mt-novolac nanocomposites were prepared by one-step in-situ intercalative polymerisation involving the simultaneous modification of the Mt with quaternary ammonium salts (QAS), polymerisation and polymer intercalation. The Mt-polymer nanocomposites were prepared using two types of QAS – with one long (C16) alkyl chain (cetyl trimethylammonium bromide) or with three medium-sized (C8) alkyl chains (tricaprylyl methylammonium chloride) – as well as without a QAS. Intercalated Mt-resol, and Mt-novolac nanocomposites were formed, as confirmed by XRD and STEM. The extent of the intercalation was higher in the Mt-resol nanocomposites and with the cetyl trimethylammonium bromide modified Mt. The presence of the Mt influenced the polymerisation process, which resulted in changes in the molecular structure of the novolac resin, an increased content of p-p linkages and a lower glass transition temperature of the resin.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

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A versatile chiral synthesis of the cross-link (+)-deoxypyridinoline (Dpd, 2) was achieved starting from vitamin B6 (7). The key steps in the synthesis of (+)-2 are transformation of B6 (7) to the chloride (3d) and construction of three alpha-amino acid chains by utilizing (R)-(-)-Schollkopf’s reagent (4), Wittig reagent (R)-(-)-5, and iodide (5)-(-)-6. (+)-Dpd (2) is a degradation product of bone collagen and has been found to be a useful marker for diagnosis of osteoporosis and other metabolic bone diseases. (C) 2000 Elsevier Science Ltd.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

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AlCl3-N,N-Dimethylaniline: A Novel Benzyl and Allyl Ether Cleavage Reagent

A combination system of AlCl3-N,N-dimethylaniline was found to cleave benzyl ethers readily to give parent alcohols in excellent yields.The system also cleaved allyl as well as methyl ethers.Numerous functional groups such as benzoyloxy, phenylthio, and olefinic double bond were not affected.Comparison of AlCl3-N,N-dimethylaniline and AlCl3-anisole were described.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

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EXAMPLE 27 10 parts by weight of a 50% strength potassium hydroxide solution are added to a solution of 150 parts (1 mol) of piperonal, 170 parts (1.1 mols) of crotonic acid piperidide and 25 g of benzyldimethylphenylammonium chloride in 100 parts by volume of anisole at 25 C. under nitrogen. The reaction mixture is stirred at 25 C. for 15 minutes and then at 60-65 C. for 2 hours, and is subsequently freed from the solvent in vacuo. The residue is stirred with 400 parts by volume of water. The reaction product obtained is filtered off, washed with water and dried. Yield of crude piperonylidenecrotonic acid piperidide: 279 parts. After recrystallisation from ethyl acetate, the yield of pure piperonylidenecrotonic acid piperidide is 251 parts (= 88% of theory). Melting point: 129-130 C.

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Reference£º
Patent; Haarman & Reimer GmbH; US4209445; (1980); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI