33454-82-9 | Page 2 of 2 | Catalyst ligands

New learning discoveries about 33454-82-9

33454-82-9 Lithium trifluoromethanesulfonate 3664839, acatalyst-ligand compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33454-82-9,Lithium trifluoromethanesulfonate,as a common compound, the synthetic route is as follows.

General procedure: To the solution of 2-Cl (186 mg, 0.25 mmol) dissolvedin5.0 mL of methanol/CH2Cl2 (1/9), a 5% aqueous solution of sodiumtetrafluoroborate (1.5 g, 0.41 mmol) was added. The solution was stirredat room temperature for 1 h. Reaction was monitored by Alumina(Al2O3) TLC plate in MeOH/CH2Cl2 (5/95); an Rf ~ 0.9 of product washigher than Rf ~ 0.5 of 2-Cl. The organic layer was passed through ashort Al2O3 flash column. The crude product was collected after solventswere removed. The product isolated as fine off white powder was obtainedafter recrystallization from isopropanol/ethyl acetate. Yield 70%;, 33454-82-9

33454-82-9 Lithium trifluoromethanesulfonate 3664839, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Wang, Ren-Tzong; Jane Tsai, Suh-Jen; Lee, Gene-Hsiang; Lai, Chung K.; Dyes and Pigments; vol. 173; (2020);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Analyzing the synthesis route of 33454-82-9

As the paragraph descriping shows that 33454-82-9 is playing an increasingly important role.

Preparation 4: Ethyl Z-5-methyl-3-(trifluoromethylsulfonyloxy)-2-hexenoateA 20L jacketed reactor was charged with DCM (2.45L), ethyl 3-oxo-5- methylhexanoate (163.3g; 1 eq) and lithiunn triflate (295.86g; 2eq) under an inert atmosphere. The resulting white suspension was stirred and cooled to 0C. N, N- Diisopropylethylamine (134.8g; 182ml; 1 .1 eq) was added over 10 minutes at <10C. The suspension was stirred for 20 minutes at 0C, then triflic anhydride (294.28g; 175ml; 1 .1 eq) was added slowly to the mixture over 30 minutes at <10C. The suspension was stirred at 0C for 1 hour.A sample of the reaction mixture was taken and partitioned between MTBE and sat. NH4CI (1 ml each). The aqueous layer was extracted with MTBE (1 ml) and the combined organic extracts were filtered through cotton wool/MgSO . Analysis by GC indicated that less than 2% starting material remained.The mixture was allowed to warm from 0 to 25C over 1 hr whilst quenching with sat. NH4CI (980ml). DCM (490ml) was added and the mixture was stirred for 5 minutes, then allowed to settle and the layers were separated. The aqueous layer was extracted with DCM (490ml). The combined organic phases were then washed with 1 M HCI (2 490ml), water (490ml) and 20% brine (490ml), then stirred for 30 minutes with MgSO4 (~165g) for 15-30 minutes. The solids were removed by filtration and washed with DCM (165ml). The filtrate was concentrated under vacuum at <40C to give an orange/brown oil containing crystalline solids. The crude product was triturated with MTBE (980ml). The mixture was filtered and the solids were washed with MTBE (2 x 165ml). The filtrate was concentrated under vacuum at <40C to give the title product as an orange/brown oil: overall yield 271 g (94%; corrected for 2.1 %w/w MTBE content); 87.7% area purity by GC. 1 H NMR (CDCI3, delta= 7.20): delta 0.94 (6H, d, J = 6.7 Hz), 1 .24 (3H, t, J = 7.2 Hz), 1 .89 (1 H, hept, J = 6.8 Hz), 2.17 (2H, d, J = 7.2 Hz), 4.18 (2H, q, J = 7.2 Hz), 5.67 (1 H, s) ppm., 33454-82-9

As the paragraph descriping shows that 33454-82-9 is playing an increasingly important role.

Reference£º
Patent; PFIZER MANUFACTURING IRELAND; BURRELL, Adam James Musgrave; MARTINEZ, Carlos Alberto; MCDAID, Paul Oliver; O’NEILL, Padraig Mary; WONG, John Wing; WO2012/25861; (2012); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Brief introduction of 33454-82-9

As the paragraph descriping shows that 33454-82-9 is playing an increasingly important role.

33454-82-9, Lithium trifluoromethanesulfonate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Was prepared in substantially the same manner as in Production Example 1, except that lithium trifluoromethanesulfonate (LiSO3CF3) was used instead of lithium bis (trifluoromethanesulfonyl) imide [Li (CF3SO2) 2N] Method 3 (CV-SO3CF3) was obtained. Was prepared in substantially the same manner as in Production Example 1, except that lithium trifluoromethanesulfonate (LiSO3CF3) was used instead of lithium bis (trifluoromethanesulfonyl) imide [Li (CF3SO2) 2N] Method 3 (CV-SO3CF3) was obtained.0.0005 mol (0.2 g) of crystal violet (Methyl violet 10B, anhydrous basis, purchased from Aldrich), which is an ionic dye containing chloride ion (Cl-), and lithium bis (trifluoromethanesulfonyl) imide (trifluoromethanesulfonyl) imide, 0.002 mol (0.57 g) of Li (CF3SO2) 2N] was added to 20 mL of acetone, and the mixture was stirred at room temperature for 3 hours. 100 mL of dichloromethane was added to the stirred mixture, and the mixture was stirred for 30 minutes. Then, 100 mL of distilled water was added to wash excess ions, and washing with distilled water was repeated three times. After the washing step, 3 g of magnesium sulfate (MgSO4) was added to remove moisture. After filtration, sample 1 (CV-N (SO2CF3) 2) was obtained (0.22 g, yield 60%) after evaporation of the solvent using a rotary evaporator

As the paragraph descriping shows that 33454-82-9 is playing an increasingly important role.

Reference£º
Patent; Kyungpook National University Industry-Academic Cooperation Foundation; Kim Seong-hun; (14 pag.)KR2018/1157; (2018); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Analyzing the synthesis route of 33454-82-9

As the paragraph descriping shows that 33454-82-9 is playing an increasingly important role.

1.43 parts by mass of 4-fluoroanisole sulfide, 1.95 parts by mass of silver tetrafluoroborate, and 1-chloromethylnaphthalene 1.77 parts by massAnd 10.0 parts by mass of acetone were uniformly mixed and reacted at 25 C for 24 hours. After removal of silver chloride,The reaction solution was transferred to a rotary evaporator, and the solvent was distilled off, and 10.0 parts by mass of acetone, 10.0 parts of hexane,By mass. 3.33 parts by mass of the obtained precipitate, 1.56 parts by mass of lithium trifluoromethanesulfonate,And 10 parts by mass of acetone were mixed and reacted at 25C for 24 hours. To the reaction solution, 10.0 g of distilled water was addedLt; / RTI & gt; The solvent was removed from the organic layer under reduced pressure, whereby 3.24 parts by mass of the compound 9 was obtained.The mass ratio of the compound B to the total mass of the compound B and the compound A was 0.965. Compared to 4-The yield of fluoroanisole sulfide was 75%. The mass of compound B was 3.13 g and the mass of compound A was 0.11 g.

As the paragraph descriping shows that 33454-82-9 is playing an increasingly important role.

Reference£º
Patent; Asahi Kasei Electronic Materials Co., Ltd.; Zhi, Cunzhong; Shang, Cunzhimi; Da, Guzhang; Dao, Tianren; (89 pag.)CN105579436; (2016); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI